Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate

已完结 10 由小太阳发布于 2024/7/16 11:38:51

DOI:10.1021/acs.oprd.2c00176
作者：Andrew T. Parsons*, Seb Caille, Marc A. Caporini, Daniel J. Griffin, Michael A. Lovette, William Powazinik IV and Gabrielle St-Pierre,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Described herein is the discovery and development of a process to prepare an atropisomeric intermediate in the synthesis of the KRAS G12C inhibitor sotorasib. Using high-throughput experimen

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上一个求助:其它数据库Naturally Fractured Carbonate Reservoir Characterization: A Case Study of a Mature High-Pour Point Oil Field in Hungary 下一个求助:American Chemical Society (ACS)Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream