Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream

已完结 10 由小太阳发布于 2024/7/16 11:39:36

DOI:10.1021/acs.oprd.2c00177
作者：Matthew G. Beaver*, Derek B. Brown, Kiersten Campbell, Yuan-Qing Fang, David D. Ford, Narbe Mardirossian, Kevin D. Nagy, Andreas R. Rötheli, Jillian W. Sheeran, Reem Telmesani and Andrew T. Parsons,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The development and kilogram-scale demonstration of a high-temperature continuous-flow racemization process to recycle the off-enantiomer of an atropisomeric sotorasib intermediate is descri

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