Development of a Scalable Enantioselective Synthesis of JAK Inhibitor Upadacitinib

已完结 10 由小太阳发布于 2024/4/19 17:12:37

DOI:10.1021/acs.oprd.1c00287
作者：Michael J. Rozema*, Lakshmi Bhagavatula, Alan Christesen, Travis B. Dunn, Andrew Ickes, Brian J. Kotecki, James C. Marek, Eric Moschetta, Westin H. Morrill, Mathew Mulhern, Michael Rasmussen, Troy Reynolds, Su Yu
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Process development of a six-stage synthesis of upadacitinib, a JAK1 inhibitor, is described. It is highlighted by an enantioselective and diastereoselective hydrogenation of a tetrasubstitu

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