供体来源的eb病毒粘膜皮肤溃疡:一个独特而复杂的直肠出血病例。

IF 1.9 Q3 TRANSPLANTATION
John Fallon, Anito Rendek, Paul Harden, Venkatesha Udupa
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引用次数: 0

摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。

Donor-derived Epstein-Barr Virus Mucocutaneous Ulceration: A Unique and Complex Case of Rectal Hemorrhage.

Donor-derived Epstein-Barr Virus Mucocutaneous Ulceration: A Unique and Complex Case of Rectal Hemorrhage.
E pstein-Barr virus (EBV) is pervasive, with a significant proportion of humans being asymptomatic carriers. Latent infection risk is an issue in the immunosuppressed because of the exerted effects of expressed viral proteins on B-lymphocyte maturation and proliferation or because of T-lymphocyte reaction. 1,2 This interaction produces a spectrum of lymphoproliferative disorders that includes EBV-mucocutaneous ulcer (MCU), in which the most severe disease process on the spectrum is posttransplant lymphoproliferative disorder (PTLD). 3 EBV-MCU is separate from PTLD, because of its indolent clinical course, without its progression to disseminated disease, and despite a significant degree of cytological atypia seen histologically. 4 Although it may not disseminate, it can be locally destructive and, in the case we discuss here, is the only EBV-MCU in the literature in the rectal mucosa to pre-sent with rectal hemorrhage. Hemorrhage in a young post-transplant patient is difficult to manage, given reluctance for multiple sensitizing blood transfusions, especially if, as in this case, they are reliant on anticoagulation.
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来源期刊
Transplantation Direct
Transplantation Direct TRANSPLANTATION-
CiteScore
3.40
自引率
4.30%
发文量
193
审稿时长
8 weeks
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