三个卫生系统中转移性乳腺癌症DPYD检测成本效益的预算影响和可转移性。

IF 1.7 4区医学 Q3 PHARMACOLOGY & PHARMACY

Personalized medicine Pub Date : 2023-07-01 Epub Date: 2023-08-14 DOI:10.2217/pme-2022-0133

Rositsa Koleva-Kolarova, Heleen Vellekoop, Simone Huygens, Matthijs Versteegh, Maureen Rutten-van Mölken, László Szilberhorn, Tamás Zelei, Balázs Nagy, Sarah Wordsworth, Apostolos Tsiachristas

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引用次数: 0

摘要

研究了在英国、荷兰和匈牙利的转移性乳腺癌症患者中，在基于氟嘧啶的化疗之前引入扩展的DPYD测试的成本效益和预算影响。使用ToxNav©进行DPYD测试在这三个国家都具有成本效益。在英国和荷兰，与没有基因检测和标准剂量的卡培他滨/5-氟尿嘧啶相比，ToxNav策略带来了更多的质量调整寿命，降低了卫生系统的成本。在匈牙利，与没有检测和标准剂量相比，ToxNav策略以更高的成本产生了更多的质量调整生命年。ToxNav战略在英国和荷兰被发现可以节省预算，而在匈牙利，它导致了额外的预算成本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Budget impact and transferability of cost-effectiveness of DPYD testing in metastatic breast cancer in three health systems.

The cost-effectiveness and budget impact of introducing extended DPYD testing prior to fluoropyrimidine-based chemotherapy in metastatic breast cancer patients in the UK, The Netherlands and Hungary were examined. DPYD testing with ToxNav^© was cost-effective in all three countries. In the UK and The Netherlands, the ToxNav strategy led to more quality-adjusted life years and fewer costs to the health systems compared with no genetic testing and standard dosing of capecitabine/5-fluorouracil. In Hungary, the ToxNav strategy produced more quality-adjusted life years at a higher cost compared with no testing and standard dose. The ToxNav strategy was found to offer budget savings in the UK and in The Netherlands, while in Hungary it resulted in additional budget costs.

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来源期刊

Personalized medicine 医学-药学

CiteScore

3.30

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Personalized Medicine (ISSN 1741-0541) translates recent genomic, genetic and proteomic advances into the clinical context. The journal provides an integrated forum for all players involved - academic and clinical researchers, pharmaceutical companies, regulatory authorities, healthcare management organizations, patient organizations and others in the healthcare community. Personalized Medicine assists these parties to shape thefuture of medicine by providing a platform for expert commentary and analysis. The journal addresses scientific, commercial and policy issues in the field of precision medicine and includes news and views, current awareness regarding new biomarkers, concise commentary and analysis, reports from the conference circuit and full review articles.