{"title":"新冠肺炎疫情第一年临床试验的方法论方面：描述性分析。","authors":"Eleni Georgiadi, Athanasios Sachlas","doi":"10.1007/s12561-023-09366-w","DOIUrl":null,"url":null,"abstract":"<p><p>In 2020, the whole planet was plagued by the extremely deadly COVID-19 pandemic. More than 83 million people had been infected with COVID-19 while more than 1.9 million people around the planet had died from this virus in the first year of the pandemic. From the first moment, the medical community started working to deal with this pandemic. For this reason, many clinical trials have been and continue to be conducted to find a safe and efficient cure for the virus. In this paper, we review the 96 clinical trials, registered in the ClinicalTrials.gov database, that had been completed by the end of the first year of the pandemic. Although the clinical trials contained significant heterogeneity in the main methodological features (enrollment, duration, allocation, intervention model, and masking) they seemed to be conducted based on an appropriate methodological basis.</p>","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":"15 2","pages":"384-396"},"PeriodicalIF":0.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019791/pdf/","citationCount":"0","resultStr":"{\"title\":\"On the Methodological Aspects of the Clinical Trials for COVID-19 Conducted in the First Year of the Pandemic: A Descriptive Analysis.\",\"authors\":\"Eleni Georgiadi, Athanasios Sachlas\",\"doi\":\"10.1007/s12561-023-09366-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In 2020, the whole planet was plagued by the extremely deadly COVID-19 pandemic. More than 83 million people had been infected with COVID-19 while more than 1.9 million people around the planet had died from this virus in the first year of the pandemic. From the first moment, the medical community started working to deal with this pandemic. For this reason, many clinical trials have been and continue to be conducted to find a safe and efficient cure for the virus. In this paper, we review the 96 clinical trials, registered in the ClinicalTrials.gov database, that had been completed by the end of the first year of the pandemic. Although the clinical trials contained significant heterogeneity in the main methodological features (enrollment, duration, allocation, intervention model, and masking) they seemed to be conducted based on an appropriate methodological basis.</p>\",\"PeriodicalId\":45094,\"journal\":{\"name\":\"Statistics in Biosciences\",\"volume\":\"15 2\",\"pages\":\"384-396\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019791/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Statistics in Biosciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12561-023-09366-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/3/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MATHEMATICAL & COMPUTATIONAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Statistics in Biosciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12561-023-09366-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/3/16 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MATHEMATICAL & COMPUTATIONAL BIOLOGY","Score":null,"Total":0}
On the Methodological Aspects of the Clinical Trials for COVID-19 Conducted in the First Year of the Pandemic: A Descriptive Analysis.
In 2020, the whole planet was plagued by the extremely deadly COVID-19 pandemic. More than 83 million people had been infected with COVID-19 while more than 1.9 million people around the planet had died from this virus in the first year of the pandemic. From the first moment, the medical community started working to deal with this pandemic. For this reason, many clinical trials have been and continue to be conducted to find a safe and efficient cure for the virus. In this paper, we review the 96 clinical trials, registered in the ClinicalTrials.gov database, that had been completed by the end of the first year of the pandemic. Although the clinical trials contained significant heterogeneity in the main methodological features (enrollment, duration, allocation, intervention model, and masking) they seemed to be conducted based on an appropriate methodological basis.
期刊介绍：
Statistics in Biosciences (SIBS) is published three times a year in print and electronic form. It aims at development and application of statistical methods and their interface with other quantitative methods, such as computational and mathematical methods, in biological and life science, health science, and biopharmaceutical and biotechnological science.
SIBS publishes scientific papers and review articles in four sections, with the first two sections as the primary sections. Original Articles publish novel statistical and quantitative methods in biosciences. The Bioscience Case Studies and Practice Articles publish papers that advance statistical practice in biosciences, such as case studies, innovative applications of existing methods that further understanding of subject-matter science, evaluation of existing methods and data sources. Review Articles publish papers that review an area of statistical and quantitative methodology, software, and data sources in biosciences. Commentaries provide perspectives of research topics or policy issues that are of current quantitative interest in biosciences, reactions to an article published in the journal, and scholarly essays. Substantive science is essential in motivating and demonstrating the methodological development and use for an article to be acceptable. Articles published in SIBS share the goal of promoting evidence-based real world practice and policy making through effective and timely interaction and communication of statisticians and quantitative researchers with subject-matter scientists in biosciences.
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