经颅交流电刺激改变听觉稳态振荡节律及其跨频耦合。

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Clinical EEG and Neuroscience Pub Date : 2024-05-01 Epub Date: 2023-06-12 DOI:10.1177/15500594231179679
Sara de la Salle, Joëlle Choueiry, Mark Payumo, Matt Devlin, Chelsea Noel, Ali Abozmal, Molly Hyde, Renée Baysarowich, Brittany Duncan, Verner Knott
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引用次数: 0

摘要

精神分裂症患者的听觉皮质可塑性缺陷可通过脑电图(EEG)得出的生物标志物得到证实,其中包括 40 赫兹听觉稳态反应(ASSR)。为了了解导致 40 赫兹听觉稳态反应的潜在振荡机制,我们研究了它对双侧颞叶经颅交变电流刺激(tACS)的反应。虽然 40-Hz ASSR 对伽马经颅交变电流刺激没有反应,但它受到了θ经颅交变电流刺激(与假经颅交变电流刺激相比)的调节,伽马功率和相位锁定的降低伴随着θ-伽马相位-振幅跨频耦合的增加。研究结果表明,频率调谐的 tACS 诱导的振荡变化可能是针对和调节正常和患病大脑听觉可塑性的一种方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transcranial Alternating Current Stimulation Alters Auditory Steady-State Oscillatory Rhythms and Their Cross-Frequency Couplings.

Auditory cortical plasticity deficits in schizophrenia are evidenced with electroencephalographic (EEG)-derived biomarkers, including the 40-Hz auditory steady-state response (ASSR). Aiming to understand the underlying oscillatory mechanisms contributing to the 40-Hz ASSR, we examined its response to transcranial alternating current stimulation (tACS) applied bilaterally to the temporal lobe of 23 healthy participants. Although not responding to gamma tACS, the 40-Hz ASSR was modulated by theta tACS (vs sham tACS), with reductions in gamma power and phase locking being accompanied by increases in theta-gamma phase-amplitude cross-frequency coupling. Results reveal that oscillatory changes induced by frequency-tuned tACS may be one approach for targeting and modulating auditory plasticity in normal and diseased brains.

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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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