不同阿尔茨海默病小鼠海马CA1区的神经振荡障碍。

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Weiming Yuan, Weijia Zhi, Lizhen Ma, Xiangjun Hu, Qian Wang, Yong Zou, Lifeng Wang
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引用次数: 0

摘要

背景:阿尔茨海默病(AD)是一种众所周知的神经退行性疾病,它会逐渐导致神经网络功能障碍和进行性记忆缺陷。神经网络活动由影响局部场电位(LFP)的节律性振荡表示。然而,AD早期海马神经节律振荡的变化在很大程度上仍未被探索。目的:研究3个月大的APP/PS1和5x-FAD小鼠的神经节律振荡,以评估AD的早期神经连接。方法:在小鼠清醒静息期,用植入的微电极阵列记录海马CA1区的LFP。Welch快速傅立叶变换、连续小波变换和相位-振幅耦合分析用于计算LFP中不同频带的功率密度和相位-幅度调制指数。结果:我们的结果显示,APP/PS1和5xFAD小鼠在清醒-静息阶段的θ、低伽马和高伽马频带功率受损。AD小鼠还表现出δ、α和β频带功率降低。在5xFAD小鼠中观察到受损的θ-低伽马和θ-高伽马相位振幅耦合。结论:本研究揭示了AD早期神经网络活动在振荡功率和交叉频率耦合方面的差异,为开发AD早期诊断的生物标志物提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neural Oscillation Disorder in the Hippocampal CA1 Region of Different Alzheimer's Disease Mice.

Background: Alzheimer's disease (AD) is a well-known neurodegenerative disease that gradually induces neural network dysfunction and progressive memory deficits. Neural network activity is represented by rhythmic oscillations that influence local field potentials (LFPs). However, changes in hippocampal neural rhythmic oscillations in the early stage of AD remain largely unexplored.

Objective: This study investigated neural rhythmic oscillations in 3-month-old APP/PS1 and 5x- FAD mice to assess early neural connectivity in AD.

Methods: LFPs were recorded from the hippocampal CA1 region with implanted microelectrode arrays while the mice were in the awake resting stage. Welch fast Fourier transforms, continuous wavelet transforms, and phase-amplitude coupling analyses were used to compute the power density of different frequency bands and phase-amplitude modulation indices in the LFPs.

Results: Our results showed impaired theta, low gamma, and high gamma frequency band power in APP/PS1 and 5xFAD mice during the awake resting stage. AD mice also showed decreased delta, alpha, and beta frequency band power. Impaired theta-low gamma and theta-high gamma phaseamplitude coupling were observed in 5xFAD mice.

Conclusion: This study revealed neural network activity differences in oscillation power and cross-frequency coupling in the early stage of AD, providing a new perspective for developing biomarkers for early AD diagnosis.

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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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