实时基因组学促进 "一体健康"。

IF 8.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Systems Biology Pub Date : 2023-08-08 Epub Date: 2023-06-16 DOI:10.15252/msb.202311686
Lara Urban, Albert Perlas, Olga Francino, Joan Martí-Carreras, Brenda A Muga, Jenniffer W Mwangi, Laura Boykin Okalebo, Jo-Ann L Stanton, Amanda Black, Nick Waipara, Claudia Fontsere, David Eccles, Harika Urel, Tim Reska, Hernán E Morales, Marc Palmada-Flores, Tomas Marques-Bonet, Mrinalini Watsa, Zane Libke, Gideon Erkenswick, Cock van Oosterhout
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引用次数: 0

摘要

自然系统的持续退化和其他环境变化将我们的社会置于一个十字路口,关系到我们与地球的未来。虽然 "一体健康 "的概念描述了人类健康如何与环境健康密不可分地联系在一起,但人们对其中许多复杂的相互依存关系仍不甚了解。在此,我们将介绍实时基因组分析的出现如何有利于 "一体健康",以及如何实现及时、深入的生态系统健康评估。我们介绍了纳米孔测序技术,该技术是目前唯一可进行实时基因组分析的颠覆性技术,已在全球范围内得到广泛应用,提高了基因组测序的可及性和多功能性。我们展示了有关人畜共患病、食品安全、环境微生物组、新兴病原体及其抗菌药耐药性以及环境健康本身的实时基因组研究--从为野生动物保护创造基因组资源到监测生物多样性、入侵物种和野生动物贩运。我们强调为什么在 "一个健康 "背景下公平获取实时基因组学至关重要,并讨论了相关的实际、法律和伦理限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Real-time genomics for One Health.

Real-time genomics for One Health.

Real-time genomics for One Health.

Real-time genomics for One Health.

The ongoing degradation of natural systems and other environmental changes has put our society at a crossroad with respect to our future relationship with our planet. While the concept of One Health describes how human health is inextricably linked with environmental health, many of these complex interdependencies are still not well-understood. Here, we describe how the advent of real-time genomic analyses can benefit One Health and how it can enable timely, in-depth ecosystem health assessments. We introduce nanopore sequencing as the only disruptive technology that currently allows for real-time genomic analyses and that is already being used worldwide to improve the accessibility and versatility of genomic sequencing. We showcase real-time genomic studies on zoonotic disease, food security, environmental microbiome, emerging pathogens, and their antimicrobial resistances, and on environmental health itself - from genomic resource creation for wildlife conservation to the monitoring of biodiversity, invasive species, and wildlife trafficking. We stress why equitable access to real-time genomics in the context of One Health will be paramount and discuss related practical, legal, and ethical limitations.

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来源期刊
Molecular Systems Biology
Molecular Systems Biology 生物-生化与分子生物学
CiteScore
18.50
自引率
1.00%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Systems biology is a field that aims to understand complex biological systems by studying their components and how they interact. It is an integrative discipline that seeks to explain the properties and behavior of these systems. Molecular Systems Biology is a scholarly journal that publishes top-notch research in the areas of systems biology, synthetic biology, and systems medicine. It is an open access journal, meaning that its content is freely available to readers, and it is peer-reviewed to ensure the quality of the published work.
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