Ana Caroline Melo Dos Santos, Barbara Rayssa Correia Dos Santos, Bruna Brandão Dos Santos, Edilson Leite de Moura, Abel Barbosa Lira Neto, Aline Cristine Pereira E Silva, Karol Fireman de Farias, Verônica de Medeiros Alves, Antônio Egídio Nardi, Elaine Virgínia Martins de Souza Figueiredo
{"title":"IL-10 (-819C/T)、TNFA (-30G/A)和ENOS (-786T/C)多态性调节可卡因成瘾者精神障碍相关预后","authors":"Ana Caroline Melo Dos Santos, Barbara Rayssa Correia Dos Santos, Bruna Brandão Dos Santos, Edilson Leite de Moura, Abel Barbosa Lira Neto, Aline Cristine Pereira E Silva, Karol Fireman de Farias, Verônica de Medeiros Alves, Antônio Egídio Nardi, Elaine Virgínia Martins de Souza Figueiredo","doi":"10.2174/17450179-v18-e2201140","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cocaine/crack use affects immune system molecules and development of mental disorders has been identified.</p><p><strong>Objective: </strong>To investigate the relationship of polymorphisms in the <i>TNFA</i> (-308G/A), IL-10 (-819C/T) and <i>ENOS</i> (-786T/C) genes with mental disorders in cocaine and crack users.</p><p><strong>Methods: </strong>A case-control study was carried out, which included 107 cocaine and crack users and 115 controls who never used healthy cocaine and crack. The SNPs in the <i>TNFA</i> (-308G/A), <i>IL-10</i> (-819C/T) and <i>ENOS</i> (-786T/C) genes were genotyped by real time PCR.</p><p><strong>Results: </strong>As for the individuals included in this study, the average age of 31.4 years (± 8.59). We identified that the G/A genotype to TNFA (-308) (OR = 0.24; p = 0.03) and the A allele (OR = 0.30; p = 0.03) were associated with reduced risk for dysthymic disorder. The T allele of the IL-10 (-819) polymorphism was associated with decreased risk of developing panic disorder (OR = 0.44; p = 0.01), while the C allele was correlated with an increased risk for alcohol dependence (OR = 1.97; p = 0.04), alcohol abuse (OR = 1.81; p = 0.04) and psychotic syndrome (OR = 2.23; p = 0.01). C/C genotype was correlated with increased chances of developing current psychotic syndrome (OR = 4.23; p = 0.01).</p><p><strong>Conclusion: </strong>Our results suggest that genetic polymorphisms promote susceptibility or promote protection for clinical phenotypes of psychiatric comorbidities in cocaine and crack users and be considered as good prognostic markers.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156023/pdf/","citationCount":"1","resultStr":"{\"title\":\"<i>IL-10 (-819C/T), TNFA (-30G/A)</i> and <i>ENOS (-786T/C)</i> Polymorphisms Modulating the Outcome Related to Mental Disorders in Crack Addicted Users.\",\"authors\":\"Ana Caroline Melo Dos Santos, Barbara Rayssa Correia Dos Santos, Bruna Brandão Dos Santos, Edilson Leite de Moura, Abel Barbosa Lira Neto, Aline Cristine Pereira E Silva, Karol Fireman de Farias, Verônica de Medeiros Alves, Antônio Egídio Nardi, Elaine Virgínia Martins de Souza Figueiredo\",\"doi\":\"10.2174/17450179-v18-e2201140\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cocaine/crack use affects immune system molecules and development of mental disorders has been identified.</p><p><strong>Objective: </strong>To investigate the relationship of polymorphisms in the <i>TNFA</i> (-308G/A), IL-10 (-819C/T) and <i>ENOS</i> (-786T/C) genes with mental disorders in cocaine and crack users.</p><p><strong>Methods: </strong>A case-control study was carried out, which included 107 cocaine and crack users and 115 controls who never used healthy cocaine and crack. The SNPs in the <i>TNFA</i> (-308G/A), <i>IL-10</i> (-819C/T) and <i>ENOS</i> (-786T/C) genes were genotyped by real time PCR.</p><p><strong>Results: </strong>As for the individuals included in this study, the average age of 31.4 years (± 8.59). We identified that the G/A genotype to TNFA (-308) (OR = 0.24; p = 0.03) and the A allele (OR = 0.30; p = 0.03) were associated with reduced risk for dysthymic disorder. The T allele of the IL-10 (-819) polymorphism was associated with decreased risk of developing panic disorder (OR = 0.44; p = 0.01), while the C allele was correlated with an increased risk for alcohol dependence (OR = 1.97; p = 0.04), alcohol abuse (OR = 1.81; p = 0.04) and psychotic syndrome (OR = 2.23; p = 0.01). C/C genotype was correlated with increased chances of developing current psychotic syndrome (OR = 4.23; p = 0.01).</p><p><strong>Conclusion: </strong>Our results suggest that genetic polymorphisms promote susceptibility or promote protection for clinical phenotypes of psychiatric comorbidities in cocaine and crack users and be considered as good prognostic markers.</p>\",\"PeriodicalId\":35447,\"journal\":{\"name\":\"Clinical Practice and Epidemiology in Mental Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156023/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Practice and Epidemiology in Mental Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/17450179-v18-e2201140\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Practice and Epidemiology in Mental Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/17450179-v18-e2201140","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
IL-10 (-819C/T), TNFA (-30G/A) and ENOS (-786T/C) Polymorphisms Modulating the Outcome Related to Mental Disorders in Crack Addicted Users.
Background: Cocaine/crack use affects immune system molecules and development of mental disorders has been identified.
Objective: To investigate the relationship of polymorphisms in the TNFA (-308G/A), IL-10 (-819C/T) and ENOS (-786T/C) genes with mental disorders in cocaine and crack users.
Methods: A case-control study was carried out, which included 107 cocaine and crack users and 115 controls who never used healthy cocaine and crack. The SNPs in the TNFA (-308G/A), IL-10 (-819C/T) and ENOS (-786T/C) genes were genotyped by real time PCR.
Results: As for the individuals included in this study, the average age of 31.4 years (± 8.59). We identified that the G/A genotype to TNFA (-308) (OR = 0.24; p = 0.03) and the A allele (OR = 0.30; p = 0.03) were associated with reduced risk for dysthymic disorder. The T allele of the IL-10 (-819) polymorphism was associated with decreased risk of developing panic disorder (OR = 0.44; p = 0.01), while the C allele was correlated with an increased risk for alcohol dependence (OR = 1.97; p = 0.04), alcohol abuse (OR = 1.81; p = 0.04) and psychotic syndrome (OR = 2.23; p = 0.01). C/C genotype was correlated with increased chances of developing current psychotic syndrome (OR = 4.23; p = 0.01).
Conclusion: Our results suggest that genetic polymorphisms promote susceptibility or promote protection for clinical phenotypes of psychiatric comorbidities in cocaine and crack users and be considered as good prognostic markers.
期刊介绍：
Clinical Practice & Epidemiology in Mental Health is an open access online journal, which publishes Research articles, Reviews, Letters in all areas of clinical practice and epidemiology in mental health covering the following topics: Clinical and epidemiological research in psychiatry and mental health; diagnosis, prognosis and treatment of mental health conditions; and frequencies and determinants of mental health conditions in the community and the populations at risk; research and economic aspects of psychiatry, with special attention given to manuscripts presenting new results and methods in the area; and clinical epidemiologic investigation of pharmaceutical agents. Clinical Practice & Epidemiology in Mental Health, a peer reviewed journal, aims to provide the most complete and reliable source of information on current developments in the field. The emphasis will be on publishing quality articles rapidly and freely available worldwide.
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