高通量三维动态杀伤试验。

IF 4.5 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2023-07-27 DOI:10.1002/eji.202350505

Renping Zhao, Archana K. Yanamandra, Bin Qu

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引用次数: 0

摘要

我们的工作提出了一种使用高含量成像的3D基质中的高通量动态杀伤测定法，这是一种强大的细胞毒性测定法，用于评估免疫杀伤细胞的杀伤效率或在生理和病理相关情况下进行药物筛选，特别是在实体瘤的情况下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A high-throughput 3D kinetic killing assay

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A high-throughput 3D kinetic killing assay

Our work presents a high-throughput kinetic killing assay in the 3D matrix using high-content imaging that is a robust and powerful cytotoxicity assay for evaluating the killing efficiency of immune killer cells or conducting drug screening under physiologically and pathologically relevant scenarios, particularly in the context of solid tumors.

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.