胃肠道发育、运动和炎症的血清素能控制。

IF 4.2 2区医学 Q1 PHYSIOLOGY

Comprehensive Physiology Pub Date : 2023-06-26 DOI:10.1002/cphy.c220024

Sarah A Najjar, Lin Y Hung, Kara Gross Margolis

{"title":"胃肠道发育、运动和炎症的血清素能控制。","authors":"Sarah A Najjar, Lin Y Hung, Kara Gross Margolis","doi":"10.1002/cphy.c220024","DOIUrl":null,"url":null,"abstract":"Although it is most well-known for its roles in central nervous system (CNS) function, the vast majority of serotonin, or 5-hydroxytryptamine (5-HT), is produced in the gastrointestinal (GI) tract. 5-HT is synthesized mostly by enterochromaffin (EC) cells of the GI epithelium and, in small part, by neurons of the enteric nervous system (ENS). The GI tract contains an array of broadly distributed 5-HT receptors, which participate in functions such as motility, sensation, inflammation, and neurogenesis. The roles of 5-HT in these functions are reviewed, as well as its role in the pathophysiology of disorders of gut-brain interaction (DGBIs) and inflammatory bowel diseases (IBD). © 2023 American Physiological Society. Compr Physiol 13:4851-4868, 2023.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373054/pdf/nihms-1916082.pdf","citationCount":"1","resultStr":"{\"title\":\"Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.\",\"authors\":\"Sarah A Najjar, Lin Y Hung, Kara Gross Margolis\",\"doi\":\"10.1002/cphy.c220024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Although it is most well-known for its roles in central nervous system (CNS) function, the vast majority of serotonin, or 5-hydroxytryptamine (5-HT), is produced in the gastrointestinal (GI) tract. 5-HT is synthesized mostly by enterochromaffin (EC) cells of the GI epithelium and, in small part, by neurons of the enteric nervous system (ENS). The GI tract contains an array of broadly distributed 5-HT receptors, which participate in functions such as motility, sensation, inflammation, and neurogenesis. The roles of 5-HT in these functions are reviewed, as well as its role in the pathophysiology of disorders of gut-brain interaction (DGBIs) and inflammatory bowel diseases (IBD). © 2023 American Physiological Society. Compr Physiol 13:4851-4868, 2023.\",\"PeriodicalId\":10573,\"journal\":{\"name\":\"Comprehensive Physiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2023-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373054/pdf/nihms-1916082.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comprehensive Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/cphy.c220024\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c220024","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}

引用次数: 1

摘要

虽然它在中枢神经系统(CNS)功能中的作用最为人所知，但绝大多数血清素或5-羟色胺(5-HT)是在胃肠道(GI)中产生的。5-HT主要由胃肠道上皮的肠色素(EC)细胞合成，小部分由肠神经系统(ENS)的神经元合成。胃肠道含有一系列广泛分布的5-羟色胺受体，它们参与运动、感觉、炎症和神经发生等功能。综述了5-羟色胺在这些功能中的作用，以及它在肠脑相互作用障碍(DGBIs)和炎症性肠病(IBD)的病理生理中的作用。©2023美国生理学会。物理学报(自然科学版)，2023。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.

Although it is most well-known for its roles in central nervous system (CNS) function, the vast majority of serotonin, or 5-hydroxytryptamine (5-HT), is produced in the gastrointestinal (GI) tract. 5-HT is synthesized mostly by enterochromaffin (EC) cells of the GI epithelium and, in small part, by neurons of the enteric nervous system (ENS). The GI tract contains an array of broadly distributed 5-HT receptors, which participate in functions such as motility, sensation, inflammation, and neurogenesis. The roles of 5-HT in these functions are reviewed, as well as its role in the pathophysiology of disorders of gut-brain interaction (DGBIs) and inflammatory bowel diseases (IBD). © 2023 American Physiological Society. Compr Physiol 13:4851-4868, 2023.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Comprehensive Physiology PHYSIOLOGY-

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.