癌症大肠癌肠道微生物组的临床诊断与治疗

IF 11.5 2区 生物学 Q1 GENETICS & HEREDITY
Yali Liu, Harry Cheuk-Hay Lau, Wing Yin Cheng, Jun Yu
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引用次数: 8

摘要

癌症(CRC)是最常见的诊断癌症之一,也是癌症相关死亡的主要原因。流行病学研究表明,遗传和环境风险因素都有助于CRC的发展。CRC的几项宏基因组研究已经确定肠道微生态失调是结直肠癌进化的一个基本风险因素。尽管在理解人类肠道微生物组与CRC之间的关系方面已经做出了巨大的努力和取得了实质性进展,但所涉及的确切机制仍然难以捉摸。最近的数据显示,肠道微生物组在CRC的DNA损伤、炎症和耐药性中起着直接的致病作用,这表明肠道微生物组的调节可以作为CRC预防和治疗的有力工具。在此,我们概述了肠道微生物组与结直肠癌之间的关系,并探讨了结直肠癌发生的相关机制。接下来,我们将强调细菌物种作为临床生物标志物的潜力,以及它们在治疗反应中的作用。进一步讨论了限制肠道微生物组临床转化的因素以及解决当前挑战的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Gut Microbiome in Colorectal Cancer: Clinical Diagnosis and Treatment

Gut Microbiome in Colorectal Cancer: Clinical Diagnosis and Treatment

Gut Microbiome in Colorectal Cancer: Clinical Diagnosis and Treatment

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and the leading cause of cancer-associated deaths. Epidemiological studies have shown that both genetic and environmental risk factors contribute to the development of CRC. Several metagenomic studies of CRC have identified gut dysbiosis as a fundamental risk factor in the evolution of colorectal malignancy. Although enormous efforts and substantial progresses have been made in understanding the relationship between human gut microbiome and CRC, the precise mechanisms involved remain elusive. Recent data have shown a direct causative role of the gut microbiome in DNA damage, inflammation, and drug resistance in CRC, suggesting that modulation of gut microbiome could act as a powerful tool in CRC prevention and therapy. Here, we provide an overview of the relationship between gut microbiome and CRC, and explore relevant mechanisms of colorectal tumorigenesis. We next highlight the potential of bacterial species as clinical biomarkers, as well as their roles in therapeutic response. Factors limiting the clinical translation of gut microbiome and strategies for resolving current challenges are further discussed.

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来源期刊
Genomics, Proteomics & Bioinformatics
Genomics, Proteomics & Bioinformatics Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
14.30
自引率
4.20%
发文量
844
审稿时长
61 days
期刊介绍: Genomics, Proteomics and Bioinformatics (GPB) is the official journal of the Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation and Genetics Society of China. It aims to disseminate new developments in the field of omics and bioinformatics, publish high-quality discoveries quickly, and promote open access and online publication. GPB welcomes submissions in all areas of life science, biology, and biomedicine, with a focus on large data acquisition, analysis, and curation. Manuscripts covering omics and related bioinformatics topics are particularly encouraged. GPB is indexed/abstracted by PubMed/MEDLINE, PubMed Central, Scopus, BIOSIS Previews, Chemical Abstracts, CSCD, among others.
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