{"title":"美国老年人膳食抗氧化剂摄入量与骨矿物质密度和骨质疏松症风险的独立和综合关联。","authors":"Qing Zhou , Xi Chen , Qiuyan Chen , Lu Hao","doi":"10.1016/j.jos.2023.07.014","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><span>The influence of dietary antioxidant intake on the occurrence and progression of </span>osteoporosis may be significant. However, to date, evidence on the link between combined effect of dietary antioxidants on bone mineral density (BMD) level and risk of osteoporosis is limited. We aimed to assess the independent and combined association of dietary antioxidant intake with BMD level and risk of osteoporosis among elderly population in United States through analysis of data in the National Health and Nutrition Examination Survey.</p></div><div><h3>Methods</h3><p><span><span>The dietary antioxidant intake was assessed based on six antioxidants, including vitamin A<span>, vitamin C, </span></span>vitamin E, zinc, selenium, and total </span>carotenoid. A composite dietary antioxidant index (CDAI) was used to evaluate the combined exposure of dietary antioxidant intake.</p></div><div><h3>Results</h3><p>A total of 5618 participants were included. Higher dietary vitamin A, vitamin C, vitamin E, zinc, selenium, and total carotenoid, were positively associated with BMD level. Compared with participants in the first quartile, those in the higher quartile of vitamin E (Q4: OR 0.652; 95% CI 0.463–0.918), zinc (Q4: OR 0.581; 95% CI 0.408–0.826), and selenium (Q3: OR 0.673; 95% CI 0.503–0.899) were associated with decreased risk of overall osteoporosis. Furthermore, compared to those in the first quartile, participants in the highest quartile of CDAI were associated with increased total femur (β 0.019; 95% CI 0.007–0.032), femur neck (β 0.020; 95% CI 0.009–0.032), trochanter (β 0.012; 95% CI 0.001–0.023), and intertrochanter BMD level (β 0.022; 95% CI 0.007–0.037); participants in the highest quartile of CDAI were associated with decreased risk of overall osteoporosis (OR 0.536; 95% CI 0.376–0.763). Furthermore, the associations of CDAI with the BMD level and osteoporosis risk were more significant among female participants.</p></div><div><h3>Conclusion</h3><p>Our study provides evidence that a combination of dietary antioxidants intake was associated increased BMD level and decreased osteoporosis risk.</p></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Independent and combined associations of dietary antioxidant intake with bone mineral density and risk of osteoporosis among elderly population in United States\",\"authors\":\"Qing Zhou , Xi Chen , Qiuyan Chen , Lu Hao\",\"doi\":\"10.1016/j.jos.2023.07.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><span>The influence of dietary antioxidant intake on the occurrence and progression of </span>osteoporosis may be significant. However, to date, evidence on the link between combined effect of dietary antioxidants on bone mineral density (BMD) level and risk of osteoporosis is limited. We aimed to assess the independent and combined association of dietary antioxidant intake with BMD level and risk of osteoporosis among elderly population in United States through analysis of data in the National Health and Nutrition Examination Survey.</p></div><div><h3>Methods</h3><p><span><span>The dietary antioxidant intake was assessed based on six antioxidants, including vitamin A<span>, vitamin C, </span></span>vitamin E, zinc, selenium, and total </span>carotenoid. A composite dietary antioxidant index (CDAI) was used to evaluate the combined exposure of dietary antioxidant intake.</p></div><div><h3>Results</h3><p>A total of 5618 participants were included. Higher dietary vitamin A, vitamin C, vitamin E, zinc, selenium, and total carotenoid, were positively associated with BMD level. Compared with participants in the first quartile, those in the higher quartile of vitamin E (Q4: OR 0.652; 95% CI 0.463–0.918), zinc (Q4: OR 0.581; 95% CI 0.408–0.826), and selenium (Q3: OR 0.673; 95% CI 0.503–0.899) were associated with decreased risk of overall osteoporosis. Furthermore, compared to those in the first quartile, participants in the highest quartile of CDAI were associated with increased total femur (β 0.019; 95% CI 0.007–0.032), femur neck (β 0.020; 95% CI 0.009–0.032), trochanter (β 0.012; 95% CI 0.001–0.023), and intertrochanter BMD level (β 0.022; 95% CI 0.007–0.037); participants in the highest quartile of CDAI were associated with decreased risk of overall osteoporosis (OR 0.536; 95% CI 0.376–0.763). Furthermore, the associations of CDAI with the BMD level and osteoporosis risk were more significant among female participants.</p></div><div><h3>Conclusion</h3><p>Our study provides evidence that a combination of dietary antioxidants intake was associated increased BMD level and decreased osteoporosis risk.</p></div>\",\"PeriodicalId\":16939,\"journal\":{\"name\":\"Journal of Orthopaedic Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Orthopaedic Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S094926582300204X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Orthopaedic Science","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S094926582300204X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
引用次数: 0
摘要
背景：膳食抗氧化剂的摄入对骨质疏松症的发生和发展可能有重大影响。然而，迄今为止，有关膳食抗氧化剂对骨矿物质密度（BMD）水平的综合影响与骨质疏松症风险之间联系的证据还很有限。我们旨在通过分析美国国家健康与营养调查的数据，评估膳食抗氧化剂摄入量与美国老年人群骨矿物质密度水平和骨质疏松症风险之间的独立和综合关联：方法：根据六种抗氧化剂（包括维生素 A、维生素 C、维生素 E、锌、硒和总类胡萝卜素）评估膳食抗氧化剂摄入量。采用综合膳食抗氧化剂指数（CDAI）来评估膳食抗氧化剂摄入量的综合影响：结果：共纳入了 5618 名参与者。较高的膳食维生素 A、维生素 C、维生素 E、锌、硒和类胡萝卜素总量与 BMD 水平呈正相关。与第一四分位数的参与者相比，维生素 E（第四季度：OR 0.652；95% CI 0.463-0.918）、锌（第四季度：OR 0.581；95% CI 0.408-0.826）和硒（第三季度：OR 0.673；95% CI 0.503-0.899）含量较高的四分位数参与者患总体骨质疏松症的风险较低。此外，与第一四分位数的参与者相比，CDAI 最高四分位数的参与者的股骨总量（β 0.019；95% CI 0.007-0.032）、股骨颈（β 0.020；95% CI 0.009-0.032）、股骨转子（β 0.012；95% CI 0.001-0.023）和转子间 BMD 水平（β 0.022；95% CI 0.007-0.037）；CDAI 最高四分位数的参与者与总体骨质疏松症风险降低相关（OR 0.536；95% CI 0.376-0.763）。此外，CDAI与骨密度水平和骨质疏松症风险的关系在女性参与者中更为显著：我们的研究提供了证据，表明膳食抗氧化剂的综合摄入与增加 BMD 水平和降低骨质疏松症风险有关。
Independent and combined associations of dietary antioxidant intake with bone mineral density and risk of osteoporosis among elderly population in United States
Background
The influence of dietary antioxidant intake on the occurrence and progression of osteoporosis may be significant. However, to date, evidence on the link between combined effect of dietary antioxidants on bone mineral density (BMD) level and risk of osteoporosis is limited. We aimed to assess the independent and combined association of dietary antioxidant intake with BMD level and risk of osteoporosis among elderly population in United States through analysis of data in the National Health and Nutrition Examination Survey.
Methods
The dietary antioxidant intake was assessed based on six antioxidants, including vitamin A, vitamin C, vitamin E, zinc, selenium, and total carotenoid. A composite dietary antioxidant index (CDAI) was used to evaluate the combined exposure of dietary antioxidant intake.
Results
A total of 5618 participants were included. Higher dietary vitamin A, vitamin C, vitamin E, zinc, selenium, and total carotenoid, were positively associated with BMD level. Compared with participants in the first quartile, those in the higher quartile of vitamin E (Q4: OR 0.652; 95% CI 0.463–0.918), zinc (Q4: OR 0.581; 95% CI 0.408–0.826), and selenium (Q3: OR 0.673; 95% CI 0.503–0.899) were associated with decreased risk of overall osteoporosis. Furthermore, compared to those in the first quartile, participants in the highest quartile of CDAI were associated with increased total femur (β 0.019; 95% CI 0.007–0.032), femur neck (β 0.020; 95% CI 0.009–0.032), trochanter (β 0.012; 95% CI 0.001–0.023), and intertrochanter BMD level (β 0.022; 95% CI 0.007–0.037); participants in the highest quartile of CDAI were associated with decreased risk of overall osteoporosis (OR 0.536; 95% CI 0.376–0.763). Furthermore, the associations of CDAI with the BMD level and osteoporosis risk were more significant among female participants.
Conclusion
Our study provides evidence that a combination of dietary antioxidants intake was associated increased BMD level and decreased osteoporosis risk.
期刊介绍：
The Journal of Orthopaedic Science is the official peer-reviewed journal of the Japanese Orthopaedic Association. The journal publishes the latest researches and topical debates in all fields of clinical and experimental orthopaedics, including musculoskeletal medicine, sports medicine, locomotive syndrome, trauma, paediatrics, oncology and biomaterials, as well as basic researches.
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