凋亡蛋白的新陈代谢作用。

Frontiers in cell death Pub Date : 2023-01-01 Epub Date: 2023-07-03 DOI:10.3389/fceld.2023.1223926
James H Schofield, Zachary T Schafer
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引用次数: 0

摘要

细胞凋亡是一种由 Caspases 激活控制的程序性细胞死亡途径,诱导细胞凋亡会导致新陈代谢发生根本性变化,从而促进或限制细胞死亡的执行。此外,新陈代谢的适应性也会对细胞是否真的启动凋亡级联产生重大影响。在这篇微型综述中,我们将重点讨论细胞凋亡调控与新陈代谢改变之间的相互联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulators mount up: the metabolic roles of apoptotic proteins.

The induction of apoptosis, a programmed cell death pathway governed by activation of caspases, can result in fundamental changes in metabolism that either facilitate or restrict the execution of cell death. In addition, metabolic adaptations can significantly impact whether cells in fact initiate the apoptotic cascade. In this mini-review, we will highlight and discuss the interconnectedness of apoptotic regulation and metabolic alterations, two biological outcomes whose regulators are intertwined.

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