测量粘蛋白结构域糖蛋白在癌症中的多方面作用。

2区医学 Q1 Medicine

Advances in Cancer Research Pub Date : 2023-01-01 Epub Date: 2022-10-08 DOI:10.1016/bs.acr.2022.09.001

Nicholas M Riley, Ru M Wen, Carolyn R Bertozzi, James D Brooks, Sharon J Pitteri

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引用次数: 0

摘要

粘蛋白结构域糖蛋白是高度O-糖基化的细胞表面和分泌蛋白，同时作为生化和生物物理调节剂。粘蛋白的异常表达和糖基化是许多恶性肿瘤的已知特征，但粘蛋白结构域糖蛋白在癌症糖生物学的广阔领域中仍然是个谜。在这里，我们通过分析和生物化学方法来研究粘蛋白在癌症中的多方面作用。我们还描述了一系列新兴的工具，这些工具专门用于在复杂的生物学背景下表征粘蛋白结构域糖蛋白。这些方法有望进一步阐明粘蛋白生物学如何被理解，并随后成为下一代癌症治疗的靶点。

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Measuring the multifaceted roles of mucin-domain glycoproteins in cancer.

Mucin-domain glycoproteins are highly O-glycosylated cell surface and secreted proteins that serve as both biochemical and biophysical modulators. Aberrant expression and glycosylation of mucins are known hallmarks in numerous malignancies, yet mucin-domain glycoproteins remain enigmatic in the broad landscape of cancer glycobiology. Here we review the multifaceted roles of mucins in cancer through the lens of the analytical and biochemical methods used to study them. We also describe a collection of emerging tools that are specifically equipped to characterize mucin-domain glycoproteins in complex biological backgrounds. These approaches are poised to further elucidate how mucin biology can be understood and subsequently targeted for the next generation of cancer therapeutics.

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来源期刊

Advances in Cancer Research 医学-肿瘤学

CiteScore

10.00

自引率

0.00%

发文量

期刊介绍： Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. The first ACR volume came out in the year that Watson and Crick reported on the central dogma of biology, the DNA double helix. In the first 100 volumes are found many contributions by some of those who helped shape the revolution and who made many of the remarkable discoveries in cancer research that have developed from it.