Huan Wang, Hui Li, Yan Wang, Cong Zhao, Qing-Wu Tian, Qing Wang, Guo-Wei He, Li-Min Lun, Chao Xuan
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Hematological parameters elucidate information involving the inflammatory and blood coagulation processes.</p><p><strong>Objectives: </strong>The current study explored the association of hematological parameters with EOCAD to identify specific risk factors.</p><p><strong>Design: </strong>A single-center retrospective case-control study was conducted with 1693 coronary artery disease patients and 1693 controls.</p><p><strong>Methods: </strong>Hematological parameters were examined through an automated analyzer.</p><p><strong>Results: </strong>The basophil percentage was significantly reduced in EOCAD (0.43 ± 0.26, <i>p</i> < 0.001) and MI (0.33 ± 0.24, <i>p</i> < 0.001) groups compared with controls (0.54 ± 0.28). The eosinophil percentage was also significantly lower in EOCAD (2.21 ± 1.71, <i>p</i> < 0.001) and MI (1.71 ± 2.44, <i>p</i> < 0.001) groups compared with controls (2.41 ± 1.75). The lymphocyte percentage in patients of EOCAD and MI and controls was 31.65 ± 7.93, 25.48 ± 9.43, and 34.82 ± 7.28, respectively. A significant difference was observed among the groups (<i>p</i> < 0.001). Except for the mean corpuscular hemoglobin (MCH), other red blood cell (RBC) parameters significantly differed between EOCAD patients and controls. The red blood cell distribution width (RDW), hematocrit (HCT), RBC count, mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and hemoglobin level were associated with EOCAD prevalence after adjusting for baseline differences. Platelet volume distribution width (PDW) also correlated with EOCAD prevalence (OR<sub>adjust</sub> = 1.087, 95% CI: 1.044-1.131).</p><p><strong>Conclusions: </strong>Hematological parameters are closely associated with EOCAD. Moreover, leukocyte parameters correlated with the presence and severity of the disease. 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引用次数: 0
摘要
背景:血栓和炎症是心血管疾病发病的关键因素。血液学参数阐明了涉及炎症和血液凝固过程的信息。目的:本研究探讨血液学参数与EOCAD的关系，以确定特定的危险因素。设计:对1693例冠心病患者和1693例对照组进行单中心回顾性病例对照研究。方法:采用全自动血液学分析仪检测血液学参数。结果:EOCAD患者嗜碱性粒细胞百分比显著降低(0.43±0.26,p p p p p调整= 1.087,95% CI: 1.044 ~ 1.131)。结论:血液学参数与EOCAD密切相关。此外，白细胞参数与疾病的存在和严重程度相关。此外，红细胞参数与疾病存在相关，但与疾病严重程度无关。血小板参数中，只有PDW与疾病存在相关。
Hematological parameters and early-onset coronary artery disease: a retrospective case-control study based on 3366 participants.
Background: Thrombosis and inflammation are crucial elements in the pathogenesis of cardiovascular disease. Hematological parameters elucidate information involving the inflammatory and blood coagulation processes.
Objectives: The current study explored the association of hematological parameters with EOCAD to identify specific risk factors.
Design: A single-center retrospective case-control study was conducted with 1693 coronary artery disease patients and 1693 controls.
Methods: Hematological parameters were examined through an automated analyzer.
Results: The basophil percentage was significantly reduced in EOCAD (0.43 ± 0.26, p < 0.001) and MI (0.33 ± 0.24, p < 0.001) groups compared with controls (0.54 ± 0.28). The eosinophil percentage was also significantly lower in EOCAD (2.21 ± 1.71, p < 0.001) and MI (1.71 ± 2.44, p < 0.001) groups compared with controls (2.41 ± 1.75). The lymphocyte percentage in patients of EOCAD and MI and controls was 31.65 ± 7.93, 25.48 ± 9.43, and 34.82 ± 7.28, respectively. A significant difference was observed among the groups (p < 0.001). Except for the mean corpuscular hemoglobin (MCH), other red blood cell (RBC) parameters significantly differed between EOCAD patients and controls. The red blood cell distribution width (RDW), hematocrit (HCT), RBC count, mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and hemoglobin level were associated with EOCAD prevalence after adjusting for baseline differences. Platelet volume distribution width (PDW) also correlated with EOCAD prevalence (ORadjust = 1.087, 95% CI: 1.044-1.131).
Conclusions: Hematological parameters are closely associated with EOCAD. Moreover, leukocyte parameters correlated with the presence and severity of the disease. In addition, erythrocyte parameters were associated with the disease presence but not with the disease severity. Among the platelet parameters, only PDW was related to the disease presence.
期刊介绍：
Therapeutic Advances in Chronic Disease publishes the highest quality peer-reviewed research, reviews and scholarly comment in the drug treatment of all chronic diseases. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers involved in the medical treatment of chronic disease, providing a forum in print and online for publishing the highest quality articles in this area.
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