膀胱结石伴良性前列腺增生:从未接受过药物治疗的患者是否必须接受前列腺手术?

IF 3 2区 医学 Q2 ANDROLOGY
Asian Journal of Andrology Pub Date : 2023-09-01 Epub Date: 2023-01-27 DOI:10.4103/aja2022107
Hakan Anil, Umut Ünal, Kaan Karamik, Ferhat Ortoglu, Hakan Erçil
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引用次数: 0

摘要

膀胱结石是前列腺手术的主要指征的历史教条最近受到了质疑。在这项研究中,我们旨在通过评估术前风险因素来预测哪些患者应该同时接受前列腺和膀胱结石手术,或者只接受膀胱结石切除。117名患有膀胱结石并伴有良性前列腺肥大(BPE)的男性被纳入研究,他们以前没有接受过药物治疗。在第一步中,只切除了患者的膀胱结石,并对BPE进行了药物治疗。在随访期间受益于药物治疗的患者被定义为第1组,因任何适应症需要前列腺手术的患者包括第2组。通过采用cox回归模型比较两组患者的术前特征来确定前列腺手术需求的危险因素。在117名膀胱结石切除并开始治疗的患者的随访中,49名(41.9%)患者有前列腺手术指征。49例患者中有33例(67.3%)的适应症为医疗失败。膀胱内前列腺增生(IPP;危险比:2.071,95%置信区间[CI]:1.05-4.05,P=0.034)和排尿后残余尿量高(危险比:1.013,95%CI:1.007-1.019,P<0.001)被发现是需要未来前列腺手术的术前危险因素。在以前没有接受过BPE药物治疗的患者中,继发于BPE的膀胱结石并不总是构成前列腺手术的指征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Bladder calculi concomitant with benign prostatic enlargement: is prostate surgery mandatory in patients who have never received medical therapy?

Bladder calculi concomitant with benign prostatic enlargement: is prostate surgery mandatory in patients who have never received medical therapy?

The historical dogma that bladder calculi comprise the main indication for prostatic surgery has recently been questioned. In this study, we aimed to predict which patients should undergo simultaneous prostate and bladder calculi surgery or only bladder calculi removal by evaluating preoperative risk factors. One hundred and seventeen men with bladder stones and concomitant benign prostate enlargement (BPE) who had not received medical treatment before were included in the study. In the first step, only the bladder calculi of patients were removed and medical treatment was given for BPE. The patients who benefited from medical treatment during the follow-up were defined as Group 1 and the patients who required prostate surgery for any indication comprised Group 2. Risk factors for prostate surgery requirements were determined by comparing preoperative characteristics between the two groups with a cox regression model. In the follow-up of 117 patients with bladder stones removed and medical treatment initiated, 49 (41.9%) patients had prostate surgery indications. The indication for 33 (67.3%) of 49 patients was medical treatment failure. The presence of intravesical prostatic protrusion (IPP; hazard ratio: 2.071, 95% confidence interval [CI]: 1.05-4.05, P = 0.034), and high postvoiding residual urine volume (hazard ratio: 1.013, 95% CI: 1.007-1.019, P < 0.001) were found to be preoperative risk factors for needing future prostate surgery. In patients who have not received medical treatment for BPE before, bladder calculi developing secondary to BPE do not always constitute an indication for prostate surgery.

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来源期刊
Asian Journal of Andrology
Asian Journal of Andrology 医学-泌尿学与肾脏学
CiteScore
4.90
自引率
3.40%
发文量
2252
审稿时长
2.2 months
期刊介绍: Fields of particular interest to the journal include, but are not limited to: -Sperm biology: cellular and molecular mechanisms- Male reproductive system: structure and function- Hormonal regulation of male reproduction- Male infertility: etiology, pathogenesis, diagnosis, treatment and prevention- Semen analysis & sperm functional assays- Sperm selection & quality and ART outcomes- Male sexual dysfunction- Male puberty development- Male ageing- Prostate diseases- Operational andrology- HIV & male reproductive tract infection- Male contraception- Environmental, lifestyle, genetic factors and male health- Male reproductive toxicology- Male sexual and reproductive health.
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