Corrigendum to: Acrolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: Involvement of RhoA/ROCK2 pathway

Zhu, Z., Lu, J., Wang, S., Peng, W., Yang, Y., Chen, C., Zhou, X., Yang, X., Xin, W., Chen, X., Pi, J., Yin, W., Yao, L., & Pi, R. (2022). Acrolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: Involvement of RhoA/ROCK2 pathway. Aging Cell, 21, e13587. https://doi.org/10.1111/acel.13587

FIGURE 2. Acrolein induced synaptic rupture in vivo by using Golgi-Cox staining. The mice were treated with acrolein (3.0 mg/kg/day) or with distilled water for 1–8 weeks. After all behavior tests, the mice were scarified and their brain tissues were harvested for GolgiCox staining and Western blot assay. (A) (a–c) The photographs of synapses in hippocampus and cortex were taken by phase contrast microscopy, cortex: 10× (a), 20× (b) and hippocampus: 40× (c). (d) Quantitative analysis of the dendrites. (B) Representative images of proteins reflecting synaptic functional expression (PSD95, SV2a, Synapsin1) in the hippocampus and cortex using western blot analysis. The data were expressed as mean ± SEM, n = 3 *p < 0.05, **p < 0.01 versus control group.

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