通过综合生物信息学分析鉴定食管癌中的新型核孔复合体相关蛋白

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biomolecular Structure & Dynamics Pub Date : 2024-09-01 Epub Date: 2023-07-28 DOI:10.1080/07391102.2023.2240414

Parisa Mohamadynejad, Mehdi Moghanibashi, Kambiz Bagheri

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引用次数: 0

摘要

核多聚酶（NUPs）是核孔复合体（NPC）的组成成分，参与大分子的核胞质转运以及许多可能导致癌变的重要过程。我们从 GEO 和 TCGA 数据中选择了三个表达谱芯片数据集，以确定食管癌中差异表达的 NUPs 基因。我们的研究结果表明，NUP133、NUP37、NUP43、NUP50、GLE1 和 NDC1 在食管癌中过度表达，其中 NUP50 和 GLE1 基因是首次在食管癌中被报道。所有确定的 NUPs 也都与远处转移有关。

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Identification of novel nuclear pore complex associated proteins in esophageal carcinoma by an integrated bioinformatics analysis.

Nucleoporins (NUPs) are components of the nuclear pore complex (NPC) that participate in the nucleocytoplasmic transport of macromolecules as well as in many essential processes that may be led to carcinogenesis. We selected three expression profile microarray datasets from GEO and as well as TCGA data to identify differentially expressed NUPs genes in esophageal carcinoma. Our findings indicated that NUP133, NUP37, NUP43, NUP50, GLE1 and NDC1 are overexpressed in esophageal carcinoma, among which NUP50 and GLE1genes are reported for the first time in esophageal carcinoma. All identified NUPs were also associated with distant metastasis.Communicated by Ramaswamy H. Sarma.

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来源期刊

Journal of Biomolecular Structure & Dynamics 生物-生化与分子生物学

CiteScore

8.90

自引率

9.10%

发文量

597

审稿时长

2 months

期刊介绍： The Journal of Biomolecular Structure and Dynamics welcomes manuscripts on biological structure, dynamics, interactions and expression. The Journal is one of the leading publications in high end computational science, atomic structural biology, bioinformatics, virtual drug design, genomics and biological networks.