Dylan Wrede, Mika Bordak, Yeabtsega Abraham, Masfique Mehedi
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引用次数: 0
摘要
表观遗传学通常是指基因受自身 DNA 序列以外的因素控制。近期研究的重点是阐明两大表观遗传现象的机制：DNA 甲基化和组蛋白修饰。由于表观遗传学涉及许多细胞过程，因此它也会影响疾病相关基因的表达，这并不奇怪。呼吸道感染、宿主细胞表观遗传调控和慢性肺部疾病之间的直接联系尚不清楚。最近的研究揭示了细菌或病毒诱导的宿主细胞表观遗传学变化。在这篇综述中，我们重点探讨了呼吸道病原体（病毒、细菌和真菌）诱导的表观遗传学调控（DNA 甲基化和组蛋白修饰），这些调控可能会促进宿主防御或允许病原体持续存在，从而对肺部疾病的病理生理学做出贡献。
Epigenetics generally involves genetic control by factors other than our own DNA sequence. Recent research has focused on delineating the mechanisms of two major epigenetic phenomena: DNA methylation and histone modification. As epigenetics involves many cellular processes, it is no surprise that it can also influence disease-associated gene expression. A direct link between respiratory infections, host cell epigenetic regulations, and chronic lung diseases is still unknown. Recent studies have revealed bacterium- or virus-induced epigenetic changes in the host cells. In this review, we focused on respiratory pathogens (viruses, bacteria, and fungi) induced epigenetic modulations (DNA methylation and histone modification) that may contribute to lung disease pathophysiology by promoting host defense or allowing pathogen persistence.
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