联合避孕环对阴道环境的影响:一项观察性的纵向研究。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-01 DOI:10.1080/13625187.2023.2228440

Filippo Murina, Alessandra Graziottin, Stefania Di Francesco, Dario Recalcati

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引用次数: 0

摘要

目的:应用16S rRNA基因测序技术，探讨复方避孕环(CVR)与阴道微生物组的关系。材料和方法:我们在一项开放标签研究中招募了20名妇女，使用CVR (NuvaRing®)，每天给予15微克炔雌醇和120微克炔雌酮，为期8周。在基线和2个月后，通过从样本中分离的总基因组DNA中扩增的16S rRNA基因测序来评估阴道微生物组。结果:2个月后细菌分布丰富度和公平性无明显变化，优势菌株为crispatus乳杆菌。只有一名患有前庭痛症和复发性外阴阴道炎的女性表现出细菌多样性的增加，并转向厌氧细菌的相对丰度。结论:我们的研究结果表明，CVR不会对阴道微生物组的组成和结构产生不利影响。然而，对于有前庭痛病史和/或复发性外阴阴道感染的患者，应特别小心。

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The impact of combined contraceptive vaginal ring on vaginal environment: an observational, longitudinal study.

Purpose: To assess the relationship between combined contraceptive vaginal ring (CVR) and vaginal microbiome using 16S rRNA gene sequencing.

Materials and methods: We enrolled 20 women for 8 weeks in an open-label study using CVR (NuvaRing^®) that delivered 15 mcg ethinylestradiol and 120 mcg etonogestrel daily. The vaginal microbiome was assessed at baseline and after 2 months by sequencing the 16S rRNA genes amplified from the total genomic DNA isolated from the sample.

Results: Bacterial distribution richness and equity did not significantly change after 2 months, and the dominant bacterial strain was Lactobacillus crispatus. Only one woman with a history of vestibulodynia and recurrent vulvovaginitis showed an increase in bacterial biodiversity, with a switch to the relative abundance of anaerobic bacteria.

Conclusions: Our results suggest that CVR does not adversely affect the composition and structure of the vaginal microbiome. However, special care should be taken in patients with a history of vestibulodynia and/or recurrent vulvovaginal infections.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.