MALAT1-乳腺癌症的相互作用:见解和影响。

IF 3.9 3区 医学 Q1 PATHOLOGY
Muhammad Tufail
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引用次数: 0

摘要

简介:癌症(BC)是一个主要的公共卫生问题,识别新的生物标志物和治疗靶点对于改善患者的预后至关重要。MALAT1是一种长的非编码RNA,由于其在BC中的过度表达和相关的不良预后,已成为一种有前途的候选者。了解MALAT1在BC进展中的作用对于制定有效的治疗策略至关重要。涵盖领域:这篇综述深入探讨了MALAT1的结构和功能,并研究了其在癌症(BC)中的表达模式及其与不同BC亚型的关系。这篇综述的重点是MALAT1和微小RNA(miRNA)之间的相互作用以及BC中涉及的各种信号通路。此外,本研究探讨了MALAT1对BC肿瘤微环境的影响以及MALAT1可能对免疫检查点调节的影响。这项研究也揭示了MALAT1在乳腺癌症耐药性中的作用。专家意见:MALAT1已被证明在BC的进展中发挥关键作用,突出了其作为潜在治疗靶点的重要性。需要进一步的研究来阐明MALAT1促进BC发展的潜在分子机制。与标准治疗相结合,需要评估针对MALAT1的治疗的潜力,这可能会改善治疗结果。此外,MALAT1作为诊断和预后标志物的研究有望改善BC的管理。继续努力破译MALAT1的功能作用并探索其临床实用性对推进BC研究领域至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The MALAT1-breast cancer interplay: insights and implications.

Introduction: Breast cancer (BC) is a major public health concern, and identifying new biomarkers and therapeutic targets is critical to improving patient outcomes. MALAT1, a long noncoding RNA, has emerged as a promising candidate due to its overexpression in BC and the associated poor prognosis. Understanding the role of MALAT1 in BC progression is paramount for the development of effective therapeutic strategies.

Covered area: This review delves into the structure and function of MALAT1, and examines its expression pattern in breast cancer (BC) and its association with different BC subtypes. This review focuses on the interactions between MALAT1 and microRNAs (miRNAs) and the various signaling pathways involved in BC. Furthermore, this study investigates the influence of MALAT1 on the BC tumor microenvironment and the possible influence of MALAT1 on immune checkpoint regulation. This study also sheds light the role of MALAT1 in breast cancer resistance.

Expert opinion: MALAT1 has been shown to play a key role in the progression of BC, highlighting its importance as a potential therapeutic target. Further studies are needed to elucidate the underlying molecular mechanisms by which MALAT1 contributes to the development of BC. In combination with standard therapy, there is a need to evaluates the potential of treatments targeting MALAT1, which may lead to improved treatment outcomes. Moreover, study of MALAT1 as a diagnostic and prognostic marker promises improved BC management. Continued efforts to decipher the functional role of MALAT1 and explore its clinical utility are critical to advancing the BC research field.

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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
71
审稿时长
1 months
期刊介绍: Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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