靶向肿瘤代谢改善免疫检查点抑制剂治疗效果

Q3 Medicine

Journal of Immunotherapy and Precision Oncology Pub Date : 2023-05-01 DOI:10.36401/JIPO-22-27

Zainab Fatima, Abdulrahman Abonofal, Bettzy Stephen

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引用次数: 1

摘要

免疫检查点抑制剂已经彻底改变了几种癌症的治疗模式。然而，并非所有患者都对治疗有反应。肿瘤细胞重编程代谢途径以促进生长和增殖。这种代谢途径的转变在肿瘤微环境中与免疫细胞激烈竞争营养物质，并产生有害于免疫细胞分化和生长的副产物。在这篇综述中，我们讨论了这些代谢改变和当前的治疗策略，以减轻这些代谢途径的改变，这些改变可以与检查点阻断联合使用，为癌症管理提供新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors.

查看原文本刊更多论文

Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors.

Immune checkpoint inhibitors have revolutionized the treatment paradigm of several cancers. However, not all patients respond to treatment. Tumor cells reprogram metabolic pathways to facilitate growth and proliferation. This shift in metabolic pathways creates fierce competition with immune cells for nutrients in the tumor microenvironment and generates by-products harmful for immune cell differentiation and growth. In this review, we discuss these metabolic alterations and the current therapeutic strategies to mitigate these alterations to metabolic pathways that can be used in combination with checkpoint blockade to offer a new path forward in cancer management.

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来源期刊

Journal of Immunotherapy and Precision Oncology Medicine-Oncology

CiteScore

2.40

自引率

0.00%

发文量