血小板ATP、甲状腺激素受体对整合素αvβ3的影响与肿瘤转移。

IF 3 4区医学 Q3 Biochemistry, Genetics and Molecular Biology

Hormones & Cancer Pub Date : 2020-02-01 DOI:10.1007/s12672-019-00371-4

Paul J Davis, Shaker A Mousa, Geraldine P Schechter, Hung-Yun Lin

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引用次数: 14

摘要

当癌细胞和血小板相互作用时，活化的血小板可能有助于肿瘤细胞的转移行为。这种相互作用需要细胞和血小板表面整合素。甲状腺激素作为l -甲状腺素(T4)是肿瘤细胞和血小板上整合素αvβ3上的激素受体的主要配体。T4激活整合素，促进血小板聚集和脱粒(局部ATP释放)，刺激肿瘤细胞增殖。通过多种分子机制，细胞外ATP促进肿瘤细胞侵袭和转移，并支持T4作为促转移因子的作用。

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Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis.

Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

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来源期刊

Hormones & Cancer ONCOLOGY-ENDOCRINOLOGY & METABOLISM

CiteScore

4.60

自引率

0.00%

发文量

期刊介绍： Hormones and Cancer is a unique multidisciplinary translational journal featuring basic science, pre-clinical, epidemiological, and clinical research papers. It covers all aspects of the interface of Endocrinology and Oncology. Thus, the journal covers two main areas of research: Endocrine tumors (benign & malignant tumors of hormone secreting endocrine organs) and the effects of hormones on any type of tumor. We welcome all types of studies related to these fields, but our particular attention is on translational aspects of research. In addition to basic, pre-clinical, and epidemiological studies, we encourage submission of clinical studies including those that comprise small series of tumors in rare endocrine neoplasias and/or negative or confirmatory results provided that they significantly enhance our understanding of endocrine aspects of oncology. The journal does not publish case studies.