昼夜节律对生理系统分子调控的影响。

IF 4.2 2区医学 Q1 PHYSIOLOGY

Comprehensive Physiology Pub Date : 2021-12-29 DOI:10.1002/cphy.c210011

G Ryan Crislip, Jermaine G Johnston, Lauren G Douma, Hannah M Costello, Alexandria Juffre, Kyla Boyd, Wendy Li, Cheoting C Maugans, Miguel Gutierrez-Monreal, Karyn A Esser, Andrew J Bryant, Andrew C Liu, Michelle L Gumz

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引用次数: 3

摘要

几乎身体的每个系统都有一个内在的细胞生物钟。在哺乳动物中，生物钟通过调节基因表达来调节多种体内平衡过程。生理系统的昼夜节律紊乱与病理生理障碍有关。在这里，我们回顾了目前对生理功能中已知昼夜节律的分子机制的理解。这篇文章的重点是人类的已知情况，以及细胞和啮齿动物模型的发现。特别地，昼夜节律钟在代谢、心血管、内分泌、肌肉骨骼、免疫和中枢神经系统的影响进行了讨论。©2021美国生理学会。中国生物医学工程学报(英文版)，2011。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.

Nearly every system within the body contains an intrinsic cellular circadian clock. The circadian clock contributes to the regulation of a variety of homeostatic processes in mammals through the regulation of gene expression. Circadian disruption of physiological systems is associated with pathophysiological disorders. Here, we review the current understanding of the molecular mechanisms contributing to the known circadian rhythms in physiological function. This article focuses on what is known in humans, along with discoveries made with cell and rodent models. In particular, the impact of circadian clock components in metabolic, cardiovascular, endocrine, musculoskeletal, immune, and central nervous systems are discussed. © 2021 American Physiological Society. Compr Physiol 11:1-30, 2021.

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来源期刊

Comprehensive Physiology PHYSIOLOGY-

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.