Guilherme da Silva Rodrigues, Isabella Harumi Yonehara Noma, Natália Yumi Noronha, Lígia Moriguchi Watanabe, Andressa Crystine da Silva Sobrinho, João Gabriel Ribeiro de Lima, Chanachai Sae-Lee, Cicero Jonas Rodrigues Benjamim, Carla Barbosa Nonino, Carlos Roberto Bueno
{"title":"八周的体育训练可降低久坐妇女两年的 DNA 甲基化年龄。","authors":"Guilherme da Silva Rodrigues, Isabella Harumi Yonehara Noma, Natália Yumi Noronha, Lígia Moriguchi Watanabe, Andressa Crystine da Silva Sobrinho, João Gabriel Ribeiro de Lima, Chanachai Sae-Lee, Cicero Jonas Rodrigues Benjamim, Carla Barbosa Nonino, Carlos Roberto Bueno","doi":"10.1080/02701367.2023.2228388","DOIUrl":null,"url":null,"abstract":"<p><p><b>Purpose</b>: The acceleration of epigenetic age is a predictor of mortality and contributes to the increase in chronic diseases. Adherence to a healthy lifestyle is a strategy to reduce epigenetic age. The present study aimed to determine whether eight weeks of combined (aerobic and strength) training (CT) can influence the epigenetic age of women between 50 and 70 years old and the differences in sites and methylated regions. <b>Methods</b>: Eighteen women (AAR<sub>Low</sub>: lower age acceleration residual, <i>n</i> = 10; AAR<sub>High</sub>: higher age acceleration residual, <i>n</i> = 8) participated in a combined exercise training program (60 minutes, 3× a week) for eight weeks. DNA was extracted from whole blood using the salting out technique. DNA methylation was performed using the array technique (Illumina's Infinium Methylation BeadChip 850k). We used the DNA Methylation Age Calculator platform to calculate the biological epigenetic age. Two-way ANOVA followed by FISHER LSD posthoc was Applied, adopting <i>p</i> < .05. <b>Results</b>: After eight weeks of CT, there were no changes to the epigenetic age acceleration for the AAR<sub>Low</sub> group (PRE: -2.3 ± 3.2 to POST: -2.3 ± 3.6). However, the AAR<sub>High</sub> group significantly decreased the age acceleration (PRE: 3.6 ± 2.6 to POST: 2.2 ± 2.7) (group effect, <i>p</i> = .01; time effect, <i>p</i> = .31; group vs. time effect, <i>p</i> = .005). <b>Conclusion</b>: CT for eight weeks benefits the epigenetic clock of women with the most accelerated age.</p>","PeriodicalId":54491,"journal":{"name":"Research Quarterly for Exercise and Sport","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women.\",\"authors\":\"Guilherme da Silva Rodrigues, Isabella Harumi Yonehara Noma, Natália Yumi Noronha, Lígia Moriguchi Watanabe, Andressa Crystine da Silva Sobrinho, João Gabriel Ribeiro de Lima, Chanachai Sae-Lee, Cicero Jonas Rodrigues Benjamim, Carla Barbosa Nonino, Carlos Roberto Bueno\",\"doi\":\"10.1080/02701367.2023.2228388\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Purpose</b>: The acceleration of epigenetic age is a predictor of mortality and contributes to the increase in chronic diseases. Adherence to a healthy lifestyle is a strategy to reduce epigenetic age. The present study aimed to determine whether eight weeks of combined (aerobic and strength) training (CT) can influence the epigenetic age of women between 50 and 70 years old and the differences in sites and methylated regions. <b>Methods</b>: Eighteen women (AAR<sub>Low</sub>: lower age acceleration residual, <i>n</i> = 10; AAR<sub>High</sub>: higher age acceleration residual, <i>n</i> = 8) participated in a combined exercise training program (60 minutes, 3× a week) for eight weeks. DNA was extracted from whole blood using the salting out technique. DNA methylation was performed using the array technique (Illumina's Infinium Methylation BeadChip 850k). We used the DNA Methylation Age Calculator platform to calculate the biological epigenetic age. Two-way ANOVA followed by FISHER LSD posthoc was Applied, adopting <i>p</i> < .05. <b>Results</b>: After eight weeks of CT, there were no changes to the epigenetic age acceleration for the AAR<sub>Low</sub> group (PRE: -2.3 ± 3.2 to POST: -2.3 ± 3.6). However, the AAR<sub>High</sub> group significantly decreased the age acceleration (PRE: 3.6 ± 2.6 to POST: 2.2 ± 2.7) (group effect, <i>p</i> = .01; time effect, <i>p</i> = .31; group vs. time effect, <i>p</i> = .005). <b>Conclusion</b>: CT for eight weeks benefits the epigenetic clock of women with the most accelerated age.</p>\",\"PeriodicalId\":54491,\"journal\":{\"name\":\"Research Quarterly for Exercise and Sport\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research Quarterly for Exercise and Sport\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02701367.2023.2228388\",\"RegionNum\":4,\"RegionCategory\":\"教育学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/7/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"HOSPITALITY, LEISURE, SPORT & TOURISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research Quarterly for Exercise and Sport","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02701367.2023.2228388","RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/7/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"HOSPITALITY, LEISURE, SPORT & TOURISM","Score":null,"Total":0}
Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women.
Purpose: The acceleration of epigenetic age is a predictor of mortality and contributes to the increase in chronic diseases. Adherence to a healthy lifestyle is a strategy to reduce epigenetic age. The present study aimed to determine whether eight weeks of combined (aerobic and strength) training (CT) can influence the epigenetic age of women between 50 and 70 years old and the differences in sites and methylated regions. Methods: Eighteen women (AARLow: lower age acceleration residual, n = 10; AARHigh: higher age acceleration residual, n = 8) participated in a combined exercise training program (60 minutes, 3× a week) for eight weeks. DNA was extracted from whole blood using the salting out technique. DNA methylation was performed using the array technique (Illumina's Infinium Methylation BeadChip 850k). We used the DNA Methylation Age Calculator platform to calculate the biological epigenetic age. Two-way ANOVA followed by FISHER LSD posthoc was Applied, adopting p < .05. Results: After eight weeks of CT, there were no changes to the epigenetic age acceleration for the AARLow group (PRE: -2.3 ± 3.2 to POST: -2.3 ± 3.6). However, the AARHigh group significantly decreased the age acceleration (PRE: 3.6 ± 2.6 to POST: 2.2 ± 2.7) (group effect, p = .01; time effect, p = .31; group vs. time effect, p = .005). Conclusion: CT for eight weeks benefits the epigenetic clock of women with the most accelerated age.
期刊介绍：
Research Quarterly for Exercise and Sport publishes research in the art and science of human movement that contributes significantly to the knowledge base of the field as new information, reviews, substantiation or contradiction of previous findings, development of theory, or as application of new or improved techniques. The goals of RQES are to provide a scholarly outlet for knowledge that: (a) contributes to the study of human movement, particularly its cross-disciplinary and interdisciplinary nature; (b) impacts theory and practice regarding human movement; (c) stimulates research about human movement; and (d) provides theoretical reviews and tutorials related to the study of human movement. The editorial board, associate editors, and external reviewers assist the editor-in-chief. Qualified reviewers in the appropriate subdisciplines review manuscripts deemed suitable. Authors are usually advised of the decision on their papers within 75–90 days.
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