肢端肥大症患者甲状腺疾病和甲状腺恶性肿瘤的评价。

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Yılmaz Cankurtaran, Güzide G Örük, Büşra Tozduman
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引用次数: 3

摘要

背景:不同地理区域的流行病学数据差异使得甲状腺疾病和甲状腺癌的患病率存在争议。以前没有研究调查过日本肢端肥大症患者的甲状腺疾病和甲状腺癌患病率是否高于普通人群。本研究的目的是确定肢端肥大症患者甲状腺疾病和甲状腺癌的患病率,并将其与对照组进行比较。方法:选取肢端肥大症患者129例(女性78例,男性51例)和对照组247例(女性151例,男性96例)作为研究对象。记录肢端肥大症患者的垂体大小、生长激素(GH)和胰岛素样生长因子(IGF)-1水平,甲状腺功能检查、甲状腺受体自身抗体(TRAb)、甲状腺显像、甲状腺超声(US)、细针穿刺细胞学(FNAC)和甲状腺切除术后的组织病理学结果。结果:肢端肥大症93例(72.1%)有甲状腺病变。肢端肥大症组弥漫性甲状腺肿(14.7%)和多结节性甲状腺肿(47.3%)发生率明显高于对照组,Graves病(4.5%)发生率明显低于对照组。肢端肥大症患者甲状腺病变和甲状腺结节的发生率明显高于肢端肥大症患者(优势比2.766;结论:肢端肥大症患者患甲状腺癌的风险是否增加尚存争议。本研究中,肢端肥大症患者甲状腺癌与对照组无明显差异,但甲状腺病变在肢端肥大症患者中明显更为常见。此外,还需要更多的研究来确定甲状腺病变是否在肢端肥大症女性患者中更为普遍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of thyroid disease and thyroid malignancy in acromegalic patients.

Background: Differences in epidemiological data from different geographical regions have made the prevalence of thyroid disease and thyroid cancer controversial. No previous study has investigated whether thyroid disease and thyroid cancer prevalence are higher in acromegalic patients than in the general population in Türkiye. The aim of this study is to determine the prevalence of thyroid disease and thyroid cancer in acromegaly and to compare it with the control group.

Methods: A total of 129 acromegalic patients (78 female, 51 male) and 247 control group patients (151 female, 96 male) were included in the study. Pituitary size, growth hormone (GH) and insulin-like growth factor (IGF)-1 levels in all patients with acromegaly and thyroid function tests, thyroid receptor autoantibody (TRAb), thyroid scintigraphy, thyroid ultrasonography (US), fine-needle aspiration cytology (FNAC) and histopathology findings after thyroidectomy were recorded.

Results: Thyroid lesions were present in 93 patients (72.1%) with acromegaly. While diffuse goiter (14.7%) and multinodular goiter (MNG) (47.3%) were significantly higher, Graves' disease (4.5%) was significantly lower in the acromegaly group compared to control group. The presence of thyroid lesions and thyroid nodules was significantly higher in patients with acromegaly (odds ratio 2.766; 95% CI 2.112-4.469, P<0.001 and OR 1.955; 95% CI 1.206-3.170, P=0.007). According to gender, the prevalence of thyroid lesions, MNG and thyroid cancer was significantly higher in female patients than in the control group. Thyroid cancer prevalence was found in 7% of acromegalic patients and the prevalence of thyroid cancer in the control group was 4.5%.

Conclusions: It remains controversial whether the risk of thyroid cancer is increased or not in patients with acromegaly. In this study, there is no significant difference in thyroid cancer between acromegaly and control group, but thyroid lesions are significantly more common in acromegaly. Also, more research is required to determine if thyroid lesions are more prevalent in females with acromegaly.

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