Delta (B.1.617.2)和其他严重急性呼吸综合征-冠状病毒变异相关的孕产妇和围产期结局比较

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Jcpsp-Journal of the College of Physicians and Surgeons Pakistan Pub Date : 2023-07-01 DOI:10.29271/jcpsp.2023.07.809

Serhat Unal, Isa Kilic, Gultekin Adanas Aydin, Hilal Gulsum Turan Ozsoy

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引用次数: 0

摘要

目的:比较德尔塔病毒(B.1.617.2)和其他SARS-CoV-2变异与孕产妇和围产期不良结局的发生率。研究设计:观察性研究。研究地点和时间:土耳其布尔萨市医院，2020年3月至2022年2月。方法:本研究纳入423例基于实时逆转录聚合酶链反应(RT-PCR)检测诊断为COVID-19的孕妇。将患者分为δ变异组(n=135)和其他变异组(n=288) (α、β、γ)，比较两组间的产妇和围产期结局。数据包括症状、实验室检查结果、放射检查结果、住院和重症监护病房(ICU)住院时间、分娩结果和死亡率。结果:delta变异组中重度肺炎发生率高于其他变异组(p=0.005)。根据世界卫生组织(WHO)的分类，delta变异组中分别有49.6%和18.5%的患者患有中度和重度疾病，而其他变异组中分别为38.5%和10.1% (p=0.001)。delta变异组中20.0%的患者和其他变异组中8.3%的患者需要ICU住院。δ变异组ICU住院时间明显延长(p=0.001)。结论:第四波疫苗接种率低的妊娠人群孕产妇发病率和死亡率升高，与三角洲变异有关。在围产儿发病率中，delta型与其他变异无显著差异。关键词:COVID-19, Delta变异，孕产妇发病率，围产期结局，不良妊娠结局

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Comparison of Maternal and Perinatal Outcomes Associated with Delta (B.1.617.2) and Other Variants of Severe Acute Respiratory Syndrome-Coronavirus 2.

Objective: To compare the frequency of adverse maternal and perinatal outcomes associated with delta (B.1.617.2) and other variants of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).

Study design: An observational study. Place and Duration of the Study: Bursa City Hospital, Bursa, Turkey, from March 2020 to February 2022.

Methodology: The study included 423 pregnant women diagnosed with COVID-19 based on real-time reverse transcriptase-polymerase chain reaction (RT-PCR) testing. The patients were divided into the delta variant (n=135) and other variants (n=288) (alpha, beta, gamma) groups, and maternal and perinatal outcomes were compared between the groups. Data including symptoms, laboratory findings, radiological findings, hospital and intensive care unit (ICU) stay, delivery outcomes, and mortality rates were recorded.

Results: The delta variant group demonstrated higher rates of moderate and severe pneumonia than the other variant group (p=0.005). According to the World Health Organization (WHO) classification, 49.6% and 18.5% of patients experienced moderate and severe disease, respectively in the delta variant group, compared to 38.5% and 10.1%, respectively in the other variant group (p=0.001). A total of 20.0% of the patients in the delta variant group and 8.3% of the patients in the other variant group required ICU stay. The length of ICU stay was significantly longer in the delta variant group (p=0.001).

Conclusion: The rates of maternal morbidity and mortality increased in the pregnant population with low rates of vaccination in the period of the fourth wave which was associated with the delta variant. No significant difference was observed in perinatal morbidity between the delta and other variants.

Key words: COVID-19, Delta variant, Maternal morbidity, Perinatal outcomes, Adverse pregnancy outcomes.

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来源期刊

Jcpsp-Journal of the College of Physicians and Surgeons Pakistan MEDICINE, GENERAL & INTERNAL-

CiteScore

1.40

自引率

0.00%

发文量

453

审稿时长

3-6 weeks

期刊介绍： Journal of College of Physicians and Surgeons Pakistan (JCPSP), is the prestigious, peer reviewed monthly biomedical journal of the country published regularly since 1991. Established with the primary aim of promotion and dissemination of medical research and contributed by scholars of biomedical sciences from Pakistan and abroad, it carries original research papers, , case reports, review articles, articles on medical education, commentaries, short communication, new technology, editorials and letters to the editor. It covers the core biomedical health science subjects, basic medical sciences and emerging community problems, prepared in accordance with the “Uniform requirements for submission to bio-medical journals” laid down by International Committee of Medical Journals Editors (ICMJE). All publications of JCPSP are peer reviewed by subject specialists from Pakistan and locally and abroad.