沙特阿拉伯Al-Ahsa地区输血依赖性镰状细胞病和β-地中海贫血患者的红细胞同种异体免疫和自身免疫

IF 2.2 Q3 HEMATOLOGY

Anemia Pub Date : 2023-01-01 DOI:10.1155/2023/3239960

Fahd A Kuriri, Abdulrahman Ahmed, Fehaid Alanazi, Fahad Alhumud, Mohammed Ageeli Hakami, Osama Atiatalla Babiker Ahmed

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引用次数: 1

摘要

发生输血相关并发症的风险，特别是同种异体免疫，是输血依赖患者持续关注的问题。确定沙特阿拉伯Al-Ahsa地区的同种异体免疫率和自身免疫率非常重要，因为沙特阿拉伯的镰状细胞病(SCD)和地中海贫血发病率最高。方法:对沙特阿拉伯Al-Ahsa法赫德国王医院(KFH) SCD合并地中海贫血患者的输血史进行横断面研究，共纳入364例输血依赖患者。结果:SCD和地中海贫血患者的同种异体免疫率分别为16.7%和11.97%，SCD和地中海贫血患者的自身免疫率分别为5.3%和0.7%。研究参与者中最常见的同种异体抗体是针对Kell、Rh血型系统的。结论:输血相关的同种异体免疫和自身免疫影响了慢性输血患者的适当管理。理想情况下，应实施扩展匹配表型以防止同种异体免疫并降低发生输血相关同种异体抗体的风险。

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Red Blood Cell Alloimmunization and Autoimmunization in Blood Transfusion-Dependent Sickle Cell Disease and β-Thalassemia Patients in Al-Ahsa Region, Saudi Arabia.

Introduction: The risk of developing transfusion-related complications, especially alloimmunization, is an ongoing concern for transfusion-dependent patients. It is important to determine the rate of alloimmunization and autoimmunization in Al-Ahsa Region, Saudi Arabia, where sickle cell disease (SCD) and thalassemia incidence rates are the highest in Saudi Arabia.

Methods: A cross-sectional study was conducted to review the transfusion history of patients with SCD and thalassemia at the King Fahad Hospital (KFH) in Al-Ahsa, Saudi Arabia. 364 transfusion-dependent patients were included in this study.

Results: Alloimmunization rates in patients with SCD and thalassemia were 16.7% and 11.97%, respectively, while autoimmunization rates in patients with SCD and thalassemia were 5.3% and 0.7%, respectively. The most frequent alloantibodies among the study participants were against Kell, Rh blood group systems.

Conclusion: Blood transfusion-related alloimmunization and autoimmunization compromise the proper management of chronically transfused patients. Ideally, extended matched phenotyping should be implemented to prevent alloimmunization and reduce the risk of developing blood transfusion-related alloantibodies.

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来源期刊

Anemia HEMATOLOGY-

CiteScore

4.80

自引率

3.40%

发文量

审稿时长

18 weeks

期刊介绍： Anemia is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all types of anemia. Articles focusing on patient care, health systems, epidemiology, and animal models will be considered, among other relevant topics. Affecting roughly one third of the world’s population, anemia is a major public health concern. The journal aims to facilitate the exchange of research addressing global health and mortality relating to anemia and associated diseases.