基于遥测的心血管药物安全性评估数据采集30年:应用与优化

IF 1.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Elham Ataei Alizadeh, Karin Graf, Jessica Schiwon, Thomas Trautmann, Florian Krause, Werner Mayer, Katrin Christ, Eric Martel, Brian D. Guth, Michael Markert
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引用次数: 0

摘要

三十年来,使用有意识的动物对新药进行安全性评估一直是我们工作组的专长。在这篇文章中,我们回顾了多年来为提高数据质量和动物受试者的福祉而面临的各种技术挑战和解决方案。我们特别感兴趣的是使用基于遥测的数据采集来进行心血管(CV)功能的研究。这包括研究中不断发展的技术方面,以及利用这种技术方法开发新的应用程序。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

Conducting safety evaluations of new drugs using conscious animals has been a specialty of our working group for thirty years. In this article, we review the various technical challenges and solutions dealt with over the years to improve both the data quality and the well being of our animal subjects. Of particular interest for us has been the use of telemetry-based data acquisition for conducting studies on cardiovascular (CV) function. This includes the evolving technical aspects of the studies, as well as the development of new applications that take advantage of this technical approach.

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来源期刊
Journal of pharmacological and toxicological methods
Journal of pharmacological and toxicological methods PHARMACOLOGY & PHARMACY-TOXICOLOGY
CiteScore
3.60
自引率
10.50%
发文量
56
审稿时长
26 days
期刊介绍: Journal of Pharmacological and Toxicological Methods publishes original articles on current methods of investigation used in pharmacology and toxicology. Pharmacology and toxicology are defined in the broadest sense, referring to actions of drugs and chemicals on all living systems. With its international editorial board and noted contributors, Journal of Pharmacological and Toxicological Methods is the leading journal devoted exclusively to experimental procedures used by pharmacologists and toxicologists.
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