生物信息学分析揭示AKR1B1在胃癌免疫浸润及临床预后中的重要作用。

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zhiyue Zhao, Zhibin Hao, Zheng Zhang, Xianbao Zhan
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引用次数: 0

摘要

浸润性免疫细胞是肿瘤微环境的重要组成部分,在胃癌的发生发展过程中发挥着复杂的作用。通过加权基因共表达网络分析,结合the Cancer Genome atlas -胃腺癌和GSE62254的数据,我们确定了Aldo-Keto Reductase Family 1 Member B (AKR1B1)是胃癌免疫调节的枢纽基因。值得注意的是,AKR1B1与较高的免疫浸润和较差的GC组织学分级相关。此外,AKR1B1是预测胃癌患者生存率的独立因素。体外实验进一步证实,过表达akr1b1的thp -1源性巨噬细胞促进GC细胞的增殖和迁移。综上所述,AKR1B1通过调节免疫微环境在胃癌进展中发挥重要作用,可能是预测胃癌预后的生物标志物,也可能是胃癌治疗的潜在靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bioinformatics Analysis Reveals the Vital Role of AKR1B1 in Immune Infiltration and Clinical Outcomes of Gastric Cancer.

Infiltrated immune cells are an important constitute of tumor microenvironment, which exert complex effects on gastric cancer (GC) pathogenesis and progression. By using weighted gene co-expression network analysis, integrating the data from The Cancer Genome Atlas-stomach adenocarcinoma and GSE62254, we identify Aldo-Keto Reductase Family 1 Member B (AKR1B1) as a hub gene for immune regulation in GC. Notably, AKR1B1 is associated with higher immune infiltration and worse histologic grade of GC. In addition, AKR1B1 is an independent factor for predicting the survival rate of GC patients. In vitro experiments further demonstrated that AKR1B1-overexpressed THP-1-derived macrophages promoted the proliferation and migration of GC cells. Taken together, AKR1B1 plays an important role in GC progression by regulating immune microenvironment, which could be a biomarker for predicting GC prognosis as well as a potential therapeutic target for GC treatment.

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来源期刊
DNA and cell biology
DNA and cell biology 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
93
审稿时长
1.5 months
期刊介绍: DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.
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