认知网络是否有助于缺血性中风后的运动恢复?

IF 3.7 2区 医学 Q1 CLINICAL NEUROLOGY
Neurorehabilitation and Neural Repair Pub Date : 2023-07-01 Epub Date: 2023-06-02 DOI:10.1177/15459683231177604
Jungsoo Lee, Yun-Hee Kim
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引用次数: 0

摘要

背景:在脑卒中患者中,保留的认知功能在运动恢复中起作用,但有关机制的证据不足。这些机制需要在人脑中进行研究,人脑是由大规模的功能专门化网络组成的。目的:利用亚急性脑卒中患者的神经影像学资料,探讨认知相关网络在上肢运动恢复中的作用。方法:回顾性分析108例亚急性缺血性脑卒中患者的队列资料。所有患者在卒中发作后2周接受静息状态功能MRI和Fugl-Meyer评估(FMA)的运动功能评估。在中风发作后3个月再次获得FMA上肢(FMA- ue)评分以评估运动恢复。为了构建静息状态网络,使用包含333个感兴趣区域的Gordon图谱进行皮质表面分割,并提取12个静息状态网络。采用线性回归方法确定FMA-UE恢复评分与静息状态网络之间的关系。结果:认知相关网络和运动相关网络与FMA-UE恢复得分相关。在运动恢复过程中,运动相关网络状态与认知相关网络状态存在交互作用。具体来说,认知相关网络与运动相关网络强度较低的患者的运动恢复有关。结论:脑卒中后运动网络损伤越大,认知相关网络在运动恢复中的作用越重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does a Cognitive Network Contribute to Motor Recovery After Ischemic Stroke?

Background: In stroke patients, preserved cognitive function plays a role in motor recovery, but there is insufficient evidence on the involved mechanisms. These mechanisms require investigation in the human brain, which is composed of large-scale functionally specialized networks.

Objective: In this study, we investigated the role of cognition-related networks on upper extremity motor recovery using neuroimaging data of subacute stroke patients.

Methods: This study retrospectively analyzed cohort data of 108 subacute ischemic stroke patients. All patients underwent resting-state functional MRI and motor function assessments using the Fugl-Meyer assessment (FMA) at 2 weeks after stroke onset. The FMA upper extremity (FMA-UE) score was obtained again at three months after stroke onset to assess motor recovery. To construct a resting-state network, cortical surface parcellation was performed using the Gordon atlas, which included 333 regions of interest, and 12 resting-state networks were extracted. Linear regression was used to identify the relationships between the FMA-UE recovery score and resting-state networks.

Results: Cognition-related networks were correlated with the FMA-UE recovery score, as were motor-related networks. Interaction effects between motor- and cognition-related network states existed in motor recovery. Specifically, cognition-related networks were associated with motor recovery in patients with a lower strength of motor-related networks.

Conclusions: These results suggested that the greater the damage to the motor network caused by stroke is, the more important the cognition-related networks are in motor recovery.

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来源期刊
CiteScore
8.30
自引率
4.80%
发文量
52
审稿时长
6-12 weeks
期刊介绍: Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal''s unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer''s disease, brain and spinal cord injuries, and peripheral nerve injuries.
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