香草酸对高脂饮食引起的糖尿病高血压模型大鼠血脂及脂质代谢酶的保护作用

Q3 Pharmacology, Toxicology and Pharmaceutics

Current drug discovery technologies Pub Date : 2023-01-01 DOI:10.2174/1570163820666230224100643

Natarajan Ashokkumar, Kolanji Vinothiya

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引用次数: 2

摘要

糖尿病是代谢综合征最常见的组成部分，包括腹部肥胖、胰岛素抵抗、高血压和脂蛋白异常血症。目的:研究香草酸对糖尿病高血压大鼠的降血脂作用。方法:选择健康雄性白化Wister大鼠(180 ~ 220 gm)。采用高脂饮食(HFD)治疗Wister大鼠糖尿病性高血压20周。对照组和糖尿病高血压大鼠给予香草酸治疗。香草酸对脂质谱(胆固醇、甘油三酯、磷脂、游离脂肪酸、高密度脂蛋白(HDL))和脂质代谢酶LPL、LCAT和HMG辅酶a还原酶的影响通过传统方法研究。为了了解香草酸的控制作用，研究了实验大鼠的脂质和代谢酶，用不同的组织学染色剂对对照动物肝组织进行了观察。结果:香草酸引起了除HDL和血浆HDL水平升高外的相当大的脂质谱降低。8周后，香草酸也能提高脂质标记酶活性(HMG辅酶a还原酶，LPL和LCAT)。此外，香草酸可以减少肝组织中胶原蛋白的积累。结论:香草酸对糖尿病高血压大鼠有降血脂作用。

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Protective Impact of Vanillic Acid on Lipid Profile and Lipid Metabolic Enzymes in Diabetic Hypertensive Rat Model Generated by a High-Fat Diet.

Introduction: Diabetes is the most common component of metabolic syndrome, including abdominal obesity, insulin resistance, hypertension, and dyslipoproteinemia.

Objective: This study aims to determine whether vanillic acid has antihyperlipidemic properties in diabetic hypertensive rats.

Methods: For this study healthy male albino Wister rats (180-220 gm) were selected. A 20-week highfat diet (HFD) was given to produce diabetic hypertension in Wister rats. Control and diabetic hypertensive rats were treated with vanillic acid. Vanillic acid effects on lipid profiles (cholesterol, triglycerides, phospholipids, free fatty acids, high-density lipoproteins (HDL)) and lipid metabolizing enzymes LPL, LCAT, and HMG CoA reductase studied by a conventional method. To understand the effect of vanillic acid control, experimental rat lipid and metabolic enzymes were studied and treated and controlled animal liver tissues were observed using the different histology staining agents.

Results: Vanillic acid caused considerable lipid profile reductions except for HDL and increased plasma HDL levels. After eight weeks of vanillic acid administration also boosts lipid marker enzyme activity (HMG CoA reductase, LPL, and LCAT). In addition, vanillic acid reduces the accumulation of collagen in liver tissues.

Conclusion: These research studies suggest that vanillic acid has antihyperlipidemic effects in diabetic hypertensive rats fed an HFD.

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.