人布鲁氏菌病的病理生理学、目前的治疗方案、候选疫苗和药物靶点。

IF 2.9 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Manisha Pritam, Rajnish Kumar
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引用次数: 0

摘要

布鲁氏菌病是由不同种类的布鲁氏菌引起的传染病。它也被称为马耳他热,是一种被忽视的疾病,可导致动物和人类感染。虽然人与人之间的感染很少见,但它可以通过吸入空气传播,如果不及时治疗,可能导致严重的健康并发症。本文综述了人类布鲁氏菌病的病理生理、预防、流行病学、缓解、治疗、药物开发靶点和疫苗开发。人类布鲁氏菌病主要由食用未经巴氏消毒的牛奶或奶制品、未煮熟的肉类和接触受感染的动物引起。人间布鲁氏菌病暴发主要与发展中国家和中低收入国家有关。布鲁氏菌在世界各地都存在,只有一些地区存在高风险,包括亚洲、非洲、东欧、墨西哥、南美和中美洲、加勒比、地中海盆地和中东。由于布鲁氏菌在细胞内存活、抑制细胞凋亡和免疫逃逸,可以在宿主细胞内存活和繁殖,从而引起慢性疾病。通过使用蛋白质组学方法,报告了几种新的人类布鲁氏菌病药物靶点,可用于开发新药。我们还可以通过探索先前报道的动物布鲁氏菌病候选疫苗,开发一种有效的人类布鲁氏菌病疫苗。本综述提供的信息将促进控制和治愈人类布鲁氏菌病及其复杂症状的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathophysiology, Current Therapeutic Options, Vaccine Candidates, and Drug Targets for Human Brucellosis.

Brucellosis is an infectious disease caused by different species of Brucella bacteria. It is also known as Malta fever, one of the neglected diseases that can cause infection in both animals and humans. Although human-to-human infection is rare, it can spread through the inhalation of airborne agents, and if left untreated, it can lead to serious health complications. In this review, we aim to highlight the pathophysiology, prevention, epidemiology, mitigation, cure, targets for drug development, and vaccine development against human brucellosis. Human brucellosis is mainly caused by consuming unpasteurized milk or dairy products, uncooked meat, and contact with infected animals. Human brucellosis outbreaks are mainly associated with developing and low- to middle-income countries. Brucella is present all over the world, and only some of the regions are at high risk, including Asia, Africa, Eastern Europe, Mexico, South and Central America, the Caribbean, the Mediterranean Basin, and the Middle East. Because of intracellular survival, inhibition of apoptosis, and immune evasion, Brucella can survive and multiply inside the host cell, which can cause chronic disease. By using proteomics approaches, several new drug targets were reported for human brucellosis that can be used for the development of novel drugs. We can also develop an efficient vaccine against human brucellosis by exploring previously reported vaccine candidates against animal brucellosis. The information provided through this review will facilitate research to control and cure human brucellosis and its complicated symptoms.

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来源期刊
Current molecular pharmacology
Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery
CiteScore
4.90
自引率
3.70%
发文量
112
期刊介绍: Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.
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