分枝杆菌VII型分泌系统。

IF 2.9 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Chemistry Pub Date : 2023-06-27 DOI:10.1515/hsz-2022-0350

Nikolaos Famelis, Sebastian Geibel, Daan van Tol

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引用次数: 0

摘要

分枝杆菌，如病原体结核分枝杆菌，利用多达五个旁系的VII型分泌系统在其细胞膜上运输蛋白质。由于这些蛋白质成对结合，在不同程度上依赖于彼此的运输，因此通往细菌表面的分泌途径仍然具有挑战性。膜内嵌入分泌机制的结构表征以及对底物运输相互依赖性的最新研究进展，首次为分泌提供了更详细和可测试的模型。

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Mycobacterial type VII secretion systems.

Mycobacteria, such as the pathogen M. tuberculosis, utilize up to five paralogous type VII secretion systems to transport proteins across their cell envelope. Since these proteins associate in pairs that depend on each other for transport to a different extent, the secretion pathway to the bacterial surface remained challenging to address. Structural characterization of the inner-membrane embedded secretion machineries along with recent advances on the substrates' co-dependencies for transport allow for the first time more detailed and testable models for secretion.

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来源期刊

Biological Chemistry 生物-生化与分子生物学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.