脂肪组织的交感神经支配:调节、功能和可塑性。

IF 4.2 2区 医学 Q1 PHYSIOLOGY
Jake W Willows, Magdalena Blaszkiewicz, Kristy L Townsend
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引用次数: 2

摘要

交感神经系统(SNS)是周围神经系统(PNS)的一个重要分支,包括儿茶酚胺能神经元,这些神经元向体内许多效应组织和器官释放去甲肾上腺素(NE)。正如几十年的外科、化学和遗传去神经支配研究所证明的那样,白色脂肪组织(WAT)和棕色脂肪组织(BAT)的SNS神经支配显然对适当的组织功能和代谢控制至关重要。尽管我们对脂肪交感神经支配有广泛的了解,特别是在SNS控制下的冷刺激褐变和产热的背景下,新的数据现在提供了一个细致入微的观点,SNS供应脂肪,包括其由局部神经免疫细胞和神经营养因子调节,调节神经肽与NE的共同释放,局部SNS驱动脂肪与循环儿茶酚胺的系统性增加的重要性。以及长期被忽视的脂肪交感神经和感觉神经之间的相互作用。本文就WAT和BAT交感神经支配模式的调控、神经供应的成像和量化、脂肪SNS对组织功能的贡献以及脂肪组织神经如何随能量需求的变化对组织重塑和可塑性的反应等方面进行了现代视角的探讨。©2023美国生理学会。中国生物医学工程学报(英文版),2009(3):481 - 481。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Sympathetic Innervation of Adipose Tissues: Regulation, Functions, and Plasticity.

The sympathetic nervous system (SNS) is a crucial arm of the peripheral nervous system (PNS) and includes catecholaminergic neurons that release norepinephrine (NE) onto numerous effector tissues and organs in the body. SNS innervation of both white (WAT) and brown adipose tissue (BAT) is clearly essential for proper tissue function and metabolic control, as decades of surgical, chemical, and genetic denervation studies have demonstrated. Despite our vast knowledge about adipose sympathetic innervation, especially in the context of cold-stimulated browning and thermogenesis that are under SNS control, newer data now provide a nuanced view of the SNS supply to adipose, including its regulation by local neuroimmune cells and neurotrophic factors, the co-release of modulatory neuropeptides along with NE, the importance of local SNS drive to adipose versus systemic increases in circulating catecholamines, and the long-overlooked interplay between adipose sympathetic and sensory nerves. This article brings a modern view to the regulation of sympathetic innervation patterns in WAT and BAT, how to image and quantify the nerve supply, contributions of adipose SNS to tissue functions, and how adipose tissue nerves respond to tissue remodeling and plasticity with changing energy demands. © 2023 American Physiological Society. Compr Physiol 13:4985-5021, 2023.

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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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