体重指数与败血症或感染性休克死亡率的关系:一项最新的荟萃分析。

IF 3.8 2区 医学 Q1 CRITICAL CARE MEDICINE
Le Bai, Jingyi Huang, Dan Wang, Dongwei Zhu, Qi Zhao, Tingyuan Li, Xianmei Zhou, Yong Xu
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引用次数: 1

摘要

背景:身体质量指数(BMI)对败血症死亡率的影响尚不清楚,因为之前的荟萃分析报告了相互矛盾的结果。最近发表的几项观察性研究提供了新的证据。因此,我们进行了这项更新的荟萃分析。方法:检索PubMed、Embase、Web of Science和Cochran Library,检索2023年2月10日前发表的论文。选择评估bmi与> 18岁脓毒症患者死亡率相关性的观察性研究。我们排除了无法获得定量综合数据的研究。比值比(OR)和95%置信区间(CI)是效果度量,它们结合使用固定效应或随机效应模型。采用纽卡斯尔-渥太华量表进行质量评估。根据潜在混杂因素进行亚组分析。结果:总体分析纳入了15项研究(105,159例患者),结果表明超重和肥胖bmi与较低的死亡率相关(OR: 0.79, 95% CI 0.70-0.88和OR: 0.74, 95% CI 0.67-0.82)。在年龄≤50岁的患者中,相关性不显著(OR: 0.89, 95% CI 0.68-1.14; OR: 0.77, 95% CI 0.50-1.18)。此外,病态肥胖与死亡率之间的关系不显著(OR: 0.91, 95% CI 0.62-1.32)。结论:超重和肥胖bmi (25.0-39.9 kg/m2)与脓毒症或感染性休克患者的死亡率降低相关,尽管并非在所有人群中都发现这种生存优势。本研究方案在PROSPERO注册(注册号CRD42023399559)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association of body mass index with mortality of sepsis or septic shock: an updated meta-analysis.

Association of body mass index with mortality of sepsis or septic shock: an updated meta-analysis.

Association of body mass index with mortality of sepsis or septic shock: an updated meta-analysis.

Association of body mass index with mortality of sepsis or septic shock: an updated meta-analysis.

Background: The effects of body mass index (BMI) on mortality of sepsis remain unknown, since previous meta-analyses have reported conflicting results. Several observational studies published recently have provided new evidence. Thus, we performed this updated meta-analysis.

Methods: PubMed, Embase, Web of Science, and Cochran Library were searched for articles published before February 10, 2023. Observational studies that assessed the association of BMIs with mortality of sepsis patients aged > 18 years were selected. We excluded studies of which data were unavailable for quantitative synthesis. Odds ratios (OR) with 95% confidence interval (CI) were the effect measure, which were combined using fixed-effect or random-effect models. The Newcastle-Ottawa Scale was applied for quality assessment. Subgroups analyses were conducted according to potential confounders.

Results: Fifteen studies (105,159 patients) were included in the overall analysis, which indicated that overweight and obese BMIs were associated with lower mortality (OR: 0.79, 95% CI 0.70-0.88 and OR: 0.74, 95% CI 0.67-0.82, respectively). The association was not significant in patients aged ≤ 50 years (OR: 0.89, 95% CI 0.68-1.14 and OR: 0.77, 95% CI 0.50-1.18, respectively). In addition, the relationship between morbidly obesity and mortality was not significant (OR: 0.91, 95% CI 0.62-1.32).

Conclusions: Overweight and obese BMIs (25.0-39.9 kg/m2) are associated with reduced mortality of patients with sepsis or septic shock, although such survival advantage was not found in all crowds. Trial registration The protocol of this study was registered in PROSPERO (registration number CRD42023399559).

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来源期刊
Journal of Intensive Care
Journal of Intensive Care Medicine-Critical Care and Intensive Care Medicine
CiteScore
11.90
自引率
1.40%
发文量
51
审稿时长
15 weeks
期刊介绍: "Journal of Intensive Care" is an open access journal dedicated to the comprehensive coverage of intensive care medicine, providing a platform for the latest research and clinical insights in this critical field. The journal covers a wide range of topics, including intensive and critical care, trauma and surgical intensive care, pediatric intensive care, acute and emergency medicine, perioperative medicine, resuscitation, infection control, and organ dysfunction. Recognizing the importance of cultural diversity in healthcare practices, "Journal of Intensive Care" also encourages submissions that explore and discuss the cultural aspects of intensive care, aiming to promote a more inclusive and culturally sensitive approach to patient care. By fostering a global exchange of knowledge and expertise, the journal contributes to the continuous improvement of intensive care practices worldwide.
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