Guan Jin, Yanhao Yang, Feng Bi, Mingyan Yang, Yinhua Ma
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引用次数: 1
摘要
前言:本研究旨在探讨血清5-羟色胺(5-HT)与中枢神经系统特异性蛋白S100b的关系，在评价创伤性脑损伤(TBI)后认知功能障碍严重程度中的应用价值。材料与方法:选择2018年6月至2020年10月在吉林省神经精神病院治疗的102例TBI患者。根据蒙特利尔认知评估(MoCA)量表，从注意力、执行功能、记忆和语言等多个层面对患者进行认知功能测试。有认知障碍的患者为研究组(n = 64)，无认知障碍的患者为对照组(n = 58)。以b水平比较两组血清5-HT和S100b。采用受试者工作特征曲线(ROC)分析血清5-HT和S100b, b在判断认知障碍中的应用价值。结果:研究组患者血清5-HT、S100b水平显著高于对照组(p < 0.05)。血清5-HT、S100b与MoCA评分呈显著负相关(r = -0.527, r = -0.436;P < 0.05, P < 0.05)。血清5-HT与S100b联合检测的ROC曲线下面积(AUC)为0.810 (95% CI: 0.742 ~ 0.936, p < 0.05)，敏感性为0.842，特异性为0.813。结论:血清5-HT、S100b水平与脑外伤患者认知功能密切相关。联合检测有助于提高认知功能障碍预测的准确性。
5-HT and S100β values in evaluating severity of cognitive impairment after traumatic brain injury.
Introduction: The aim of the study was to investigate the relationship between serum serotonin (5-HT) and central nervous system specific protein S100b application value in evaluating the severity of cognitive impairment after traumatic brain injury (TBI).
Material and methods: 102 patients with TBI treated in Jilin Neuropsychiatric Hospital from June 2018 to October 2020 were selected. According to Montreal Cognitive Assessment (MoCA) scale, patients were tested for cognitive function from multiple levels, such as attention, executive function, memory, and language. Patients with cognitive impairment were included into study group ( n = 64), and those without cognitive impairment were assigned to control group ( n = 58). Serum 5-HT and S100b were compared between the two groups with b level. Serum 5-HT and S100b were analyzed by receiver operating characteristic curve (ROC), b application value judging cognitive impairment.
Results: Serum 5-HT and S100b levels in the study group were significantly higher than those in the control group ( p < 0.05). In serum 5-HT and S100b, there was a significant negative correlation with a MoCA score ( r = -0.527, r = -0.436; p < 0.05, p < 0.05). Combined detection of serum 5-HT and S100b's area under ROC curve (AUC) was 0.810 (95% CI: 0.742-0.936, p < 0.05), sensitivity was 0.842, and specificity was 0.813.
Conclusions: Serum 5-HT and S100b levels are closely related to the cognitive function of TBI patients. Combined detection is helpful to improve the accuracy of predicting cognitive impairment.
期刊介绍：
Folia Neuropathologica is an official journal of the Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. The journal publishes original articles and reviews that deal with all aspects of clinical and experimental neuropathology and related fields of neuroscience research. The scope of journal includes surgical and experimental pathomorphology, ultrastructure, immunohistochemistry, biochemistry and molecular biology of the nervous tissue. Papers on surgical neuropathology and neuroimaging are also welcome. The reports in other fields relevant to the understanding of human neuropathology might be considered.
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