富含白细胞和血小板的纤维蛋白在治疗药物相关性颌骨骨坏死中的作用:一项系统综述和荟萃分析。

IF 2.2 3区 医学
A Muñoz-Salgado, F-F Silva, M-E Padín-Iruegas, G-C Camolesi, W-E Bernaola-Paredes, H-R Veronese, M-D Celestino, W-J Filho, A-I Lorenzo-Pouso, M Pérez-Sayáns
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引用次数: 1

摘要

背景:使用含氮双膦酸盐后,颌骨骨坏死(ONJ)经常出现不良反应,因为非含氮双膦酸盐代谢更快,产生这种影响的程度较小。本研究的目的是通过系统回顾和荟萃分析来分析文献中关于使用L-PRF治疗ONJ的结果。材料和方法:从Medline (PubMed)、Cochrane、Web of Science和灰色文献数据库中筛选出10份。结果:在完全消退的meta分析中,联合使用L-PRF治疗ONJ,获得完全消退的加权比例(PP)为94.3% (95% CI: 91.2 ~ 97.4)。结论:单独使用L-PRF或联合其他疗法治疗ONJ,病变完全消退的百分比较高(94.3%)。在将L-PRF与其他治疗方法联合使用以及单独分析其他治疗方法的有效性的研究中,L-PRF已显示出更高的治愈率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Leukocyte and platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: A systematic review and meta-analysis.

Leukocyte and platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: A systematic review and meta-analysis.

Leukocyte and platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: A systematic review and meta-analysis.

Leukocyte and platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: A systematic review and meta-analysis.

Background: Osteonecrosis of the jaw (ONJ) has a frequent adverse effect after the administration of nitrogenous bisphosphonates, as non-nitrogenous bisphosphonates are metabolized more rapidly and would produce this effect to a lesser extent. The objective of this study is to analyze the results obtained in the literature with the use of L-PRF in the treatment of ONJ through a systematic review and meta-analysis.

Material and methods: Medline (via PubMed), Cochrane, Web of Science and Grey Literature Database was screened from which 10 were selected.

Results: In the meta-analysis with full resolution, combining the use of L-PRF in the treatment of ONJ, a weighted proportion (PP) of 94.3% of complete resolution is obtained (95% CI: 91.2-97.4, p<0.001), with a low degree of heterogeneity, statistically significant (I2 = 29.02%; p<0.001). When analyzing the non-resolution data, a weighted proportion (PP) of 7.7% (95% CI: 3.6-11.9; p<0.001) was obtained with moderate heterogeneity (I2: 41.87%; p=0.112). In the meta-regression, no significant correlation was found between complete resolution and year of publication (intercept = 2.88, p=0.829). In consistency analysis no major changes in PP are identified when any of the studies are eliminated, demonstrating a high reliability in the combined results.

Conclusion: L-PRF alone or in combination with other therapies in treatment of ONJ achieved high percentages of complete lesion resolution (94.3%). In studies where L-PRF is combined with other therapies, and where the effectiveness of the other therapy alone is analyzed, L-PRF has been shown higher percentages of resolution.

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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
52
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
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