托斯卡纳(意大利)封锁期间空气污染减少:对精子DNA断裂有影响吗?

IF 2.3 4区 医学 Q3 ENVIRONMENTAL SCIENCES
Costanza Calamai, Oumaima Ammar, Sara Marchiani, Selene Degl'Innocenti, Marisa Fino, Lorenzo Righi, Sara Dabizzi, Mario Maggi, Elisabetta Baldi, Linda Vignozzi, Monica Muratori
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引用次数: 0

摘要

2020年3月,意大利政府实施了全国封锁,并于2020年6月几乎完全取消。由于人类活动的突然停止,大气污染物的排放量减少了。空气污染是导致非传染性疾病和死亡的环境风险因素。新出现的证据也表明它在男性不育中起作用。在这项研究中,我们比较了在一个意大利中心进行sDF测定和常规精液分析的受试者在锁定前(N = 119)和锁定后(N = 105)约6个月内的精子DNA碎片(sDF)水平和常规精液参数。锁锁后,我们发现精子进行性活力(48.00[38.50-58.00]%比42.00[33.00-53.00]%)和sDF水平(总计:24.79[18.33-33.97]%比35.02[25.04-45.73]%,p <亮:14.02 (10.69 - -17.93)% vs 18.54 (13.58 - -25.82) %, p & lt;。sDF: 9.24[5.64-15.78]% vs. 12.24[8.08-19.10]%, p < 0.01),反映了白细胞精液浓度的降低(p < 0.01)。在调整白细胞浓度和几种已知影响精子活力和/或sDF水平的条件后,精子活力和DNA质量的改善得以维持。托斯卡纳在封锁期间和之后观察到空气污染显著减少,在不育诊所就诊的患者中,精子活力和DNA质量的相关改善表明空气污染在男性不育中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Decrease of air pollution during lockdown in Tuscany (Italy): An effect on sperm DNA fragmentation?

Decrease of air pollution during lockdown in Tuscany (Italy): An effect on sperm DNA fragmentation?

In March 2020, the Italian government imposed a national lockdown which was almost completely removed in June 2020. Due to the abrupt stop of human activities, emissions of air pollutants decreased. Air pollution is an environmental risk factor for noncommunicable disease and mortality. Emerging evidence also suggests a role in male infertility. In this study, we compared sperm DNA fragmentation (sDF) levels and conventional semen parameters between subjects undergoing sDF determination and routine semen analysis in a single Italian centre, during about 6 months before (N = 119) and after lockdown (N = 105). After lockdown, we found an improvement of sperm progressive motility (48.00[38.50–58.00]% vs. 42.00[33.00–53.00]%) and sDF levels (as total: 24.79[18.33–33.97]% vs. 35.02[25.04–45.73]%, p < .001; brighter: 14.02[10.69–17.93]% vs 18.54[13.58–25.82]%, p < .001 and dimmer sDF: 9.24[5.64–15.78]% vs. 12.24[8.08–19.10]%, p < .01), mirrored by a decrease of leukocyte semen concentration (p < .01). The improvement of sperm motility and DNA quality was maintained after adjusting for leukocyte concentration and several conditions known to affect sperm motility and/or sDF levels. With a significant decrease in air pollution observed in Tuscany during and after lockdown, associated improvement in sperm motility and DNA quality in patients referred to the infertility clinic is suggestive of the potential role of air pollution in male infertility.

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来源期刊
CiteScore
5.40
自引率
10.70%
发文量
52
审稿时长
12-24 weeks
期刊介绍: Environmental and Molecular Mutagenesis publishes original research manuscripts, reviews and commentaries on topics related to six general areas, with an emphasis on subject matter most suited for the readership of EMM as outlined below. The journal is intended for investigators in fields such as molecular biology, biochemistry, microbiology, genetics and epigenetics, genomics and epigenomics, cancer research, neurobiology, heritable mutation, radiation biology, toxicology, and molecular & environmental epidemiology.
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