神经营养素与中枢神经系统:系统综述。

Q3 Psychology
Carlos Alberto Nogueira-de-Almeida, Idiberto José Zotarelli-Filho, Maria Eduarda Nogueira-de-Almeida, Caio Gonçalves Souza, Vitorio Luis Kemp, Williams Santos Ramos
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引用次数: 3

摘要

大脑是人体中最复杂的器官,对输入的需求很高且持续不断。充足的营养对于大脑的完整功能至关重要,不仅是因为能量的供应,主要来自碳水化合物,而且还因为其他大量营养素和微量营养素的充足供应,以合成神经递质和蛋白质成分。饮食中的维生素、矿物质和其他成分也构成了所谓的“神经营养素”。目的:这是一个系统的回顾,以突出关键的神经营养素和临床研究,指导适当的营养状态策略。方法:采用系统评价- prisma平台规则。该研究于2021年10月至2022年2月进行,并基于Scopus, PubMed, Science Direct, Scielo和Google Scholar开发。研究质量采用GRADE评分工具,偏倚风险采用Cochrane评分工具进行分析。结果:共发现文献234篇,全文评价167篇,纳入评价118篇。根据GRADE工具,大多数研究(>50%)遵循对照临床研究模型,并具有良好的方法学设计。总体评估结果为54项研究,样本量小,偏倚风险高。神经营养中最重要的常量营养素是磷脂酰丝氨酸和色氨酸。微量营养素有甲基叶酸、维生素B6和B12、镁、精氨酸、胆碱和烟酸。结论:神经病学和精神病学领域在预防和病理生理学知识的深化以及在既定疾病的治疗方面取得了巨大进展。目前,人们越来越认识到营养作为这些过程的辅助作用。对神经营养物质科学基础的研究表明,与这一主题相关的出版物有了很大的增长。在本文中,对其中一些营养物质进行了探讨,以验证目前的知识状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuronutrients and Central Nervous System: A Systematic Review.

Introduction: The brain is the most complex organ in the human body, with a high and constant demand for inputs. Adequate nutrition is essential for the complete functioning of the brain, not only due to the energy supply, mainly from carbohydrates, but also due to the adequate supply of other macronutrients and micronutrients for the synthesis of neurotransmitters and protein components. Vitamins, minerals, and other components of the diet also constitute the so-called "neuro-nutrients".

Objective: It was to develop a systematic review to highlight key neuro-nutrients and clinical studies that direct strategies for adequate nutritional status.

Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from October 2021 to February 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument.

Results: A total of 234 articles were found and 167 articles were evaluated in full, and 118 were included and evaluated in the present study. According to the GRADE instrument, most studies (>50%) followed a controlled clinical study model and had a good methodological design. The overall assessment resulted in 54 studies with a high risk of bias to the small sample size. The most important macronutrients in neuro-nutrition are phosphatidylserine and tryptophan. Micronutrients are methyl folate, vitamins B6 and B12, magnesium, arginine, choline, and niacin.

Conclusion: The areas of neurology and psychiatry have shown great advances regarding the deepening of knowledge in prophylaxis and pathophysiology, as well as in the treatment of established diseases. The recognition of the role of nutrition as an adjunct to these processes is currently growing. The search in scientific bases for neuro nutrients reveals a great growth of publications related to this theme. In the present text, some of these nutrients were explored to verify the current state of knowledge.

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来源期刊
Central nervous system agents in medicinal chemistry
Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology
CiteScore
2.10
自引率
0.00%
发文量
21
期刊介绍: Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
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