减肥改变肥胖狗的脂质过氧化和对称二甲基精氨酸水平。

IF 1.1 4区 农林科学 Q2 Veterinary
Carolina Zaghi Cavalcante, Pedro Vicente Michelotto, Luiz Guilherme Achnar Capriglione, Andressa Thais Roncoski, Anita Nishiyama
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引用次数: 0

摘要

在肥胖犬中,氧化应激与炎症过程和全身内分泌失衡有关。监测氧化状态是肥胖控制的早期和有价值的手段,因为它是体重减轻的标志,导致氧化状态或损伤潜力的减少。本研究的目的是研究肥胖雌性犬在接受8周减肥计划后,体内硫代巴比妥酸活性物质(TBARS)和对称二甲基精氨酸(SDMA)浓度的变化。我们纳入了没有合并症且身体状况评分(BCS)为8分和9分(满分9分)的肥胖母狗。除了TBARS和SDMA评估外,血液和尿液的实验室测试(血细胞计数;血清生化水平;白蛋白、丙氨酸转氨酶、碱性磷酸酶、肌酐、尿素、甘油三酯、胆固醇和葡萄糖;验尿;以及蛋白尿)、收缩压和激素浓度(胰岛素、皮质醇和游离甲状腺素)在减肥计划前后进行了测量。所有肥胖犬的TBARS水平均较高。项目结束后,狗的TBARS (P = 0.005)和SDMA (P = 0.0013)显著降低。综上所述,肥胖母狗在8周的减肥计划后容易发生脂质过氧化,TBARS和SDMA水平下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Weight loss modifies lipid peroxidation and symmetric dimethylarginine levels in obese dogs.

In obese dogs, oxidative stress is associated with inflammatory processes and systemic endocrine imbalances. Monitoring oxidative status is an early and valuable means of obesity control as it is a marker of weight loss, which leads to a reduction in oxidative status or injury potential. The objective of this study was to investgate the changes in the concentrations of thiobarbituric acid reactive substances (TBARS) and symmetric dimethylarginine (SDMA) in obese female dogs subjected to an 8-week weight-loss program. We included obese female dogs without comorbidities and with body condition scores (BCS) of 8 and 9 out of 9. In addition to TBARS and SDMA assessments, laboratory tests of blood and urine (blood count; levels of serum biochemistry; albumin, alanine aminotransferase, alkaline phosphatase, creatinine, urea, triglycerides, cholesterol, and glucose; urinalysis; and albuminuria), systolic blood pressure, and hormone concentrations (insulin, cortisol, and free thyroxine) were carried out before and after the weight-loss program. All the obese dogs presented high TBARS levels. After the program, the dogs showed significant reductions in TBARS (P = 0.005) and SDMA (P = 0.0013). In conclusion, obese female dogs were prone to lipid peroxidation and the TBARS and SDMA levels decreased after the 8-week weight-loss program.

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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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