犬类疾病基因组学视角作为人类疾病研究模型的综述。

IF 1.1 4区农林科学 Q2 Veterinary

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2023-01-01

Bhawanpreet Kaur, Jaswinder Kaur, Neeraj Kashyap, Jaspreet Singh Arora, Chandra Sekhar Mukhopadhyay

{"title":"犬类疾病基因组学视角作为人类疾病研究模型的综述。","authors":"Bhawanpreet Kaur, Jaswinder Kaur, Neeraj Kashyap, Jaspreet Singh Arora, Chandra Sekhar Mukhopadhyay","doi":"","DOIUrl":null,"url":null,"abstract":"The domestic dog has been given considerable attention as a system for investigating the genetics of human diseases. Population diversity and breed structure are unique features that make dogs particularly amenable to genetic studies. Dogs show distinguished features of breed-specific homogeneity, which is associated with striking interbreed heterogeneity. This review discusses the significance of studying the genetic maps, genome-wide association studies (GWAS), and usefulness of this species as an animal model. Most canine genetic disorders are similar to those of humans, including inherited, psychiatric, and genetic disorders. In addition to revealing new candidate genes, canine models allow access to experimental resources, such as cells, tissues, and even live animals, for research and intervention purposes.","PeriodicalId":9550,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"87 1","pages":"3-8"},"PeriodicalIF":1.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808881/pdf/cjvr_01_3.pdf","citationCount":"0","resultStr":"{\"title\":\"A comprehensive review of genomic perspectives of canine diseases as a model to study human disorders.\",\"authors\":\"Bhawanpreet Kaur, Jaswinder Kaur, Neeraj Kashyap, Jaspreet Singh Arora, Chandra Sekhar Mukhopadhyay\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The domestic dog has been given considerable attention as a system for investigating the genetics of human diseases. Population diversity and breed structure are unique features that make dogs particularly amenable to genetic studies. Dogs show distinguished features of breed-specific homogeneity, which is associated with striking interbreed heterogeneity. This review discusses the significance of studying the genetic maps, genome-wide association studies (GWAS), and usefulness of this species as an animal model. Most canine genetic disorders are similar to those of humans, including inherited, psychiatric, and genetic disorders. In addition to revealing new candidate genes, canine models allow access to experimental resources, such as cells, tissues, and even live animals, for research and intervention purposes.\",\"PeriodicalId\":9550,\"journal\":{\"name\":\"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire\",\"volume\":\"87 1\",\"pages\":\"3-8\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808881/pdf/cjvr_01_3.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Veterinary\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","FirstCategoryId":"97","ListUrlMain":"","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Veterinary","Score":null,"Total":0}

引用次数: 0

摘要

作为一种研究人类疾病遗传学的系统，家养狗已经受到了相当大的关注。种群多样性和品种结构是狗的独特特征，使它们特别适合基因研究。狗表现出品种特异性同质性的显著特征，这与显著的杂交异质性有关。本文综述了该物种遗传图谱研究的意义、全基因组关联研究(GWAS)以及该物种作为动物模型的可行性。大多数犬类遗传疾病与人类相似，包括遗传病、精神疾病和遗传疾病。除了揭示新的候选基因，犬类模型还允许访问实验资源，如细胞，组织，甚至活体动物，用于研究和干预目的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

A comprehensive review of genomic perspectives of canine diseases as a model to study human disorders.

The domestic dog has been given considerable attention as a system for investigating the genetics of human diseases. Population diversity and breed structure are unique features that make dogs particularly amenable to genetic studies. Dogs show distinguished features of breed-specific homogeneity, which is associated with striking interbreed heterogeneity. This review discusses the significance of studying the genetic maps, genome-wide association studies (GWAS), and usefulness of this species as an animal model. Most canine genetic disorders are similar to those of humans, including inherited, psychiatric, and genetic disorders. In addition to revealing new candidate genes, canine models allow access to experimental resources, such as cells, tissues, and even live animals, for research and intervention purposes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 农林科学-兽医学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.