核糖体合成和翻译后修饰肽的发现、生物工程和生物活性评价的最新进展

IF 3.8 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Guannan Zhong, Zong-Jie Wang, Fu Yan, Youming Zhang and Liujie Huo*, 
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引用次数: 6

摘要

核糖体合成和翻译后修饰肽(RiPP)在天然产物和药物发现方面越来越受到关注。这不仅赋予了天然产物独特的化学结构和拓扑结构,还赋予了其优异的生物活性,如抗菌、抗真菌、抗病毒等。基因组学、生物信息学和化学分析的进步促进了RiPP的指数增长及其生物活性的评估。此外,得益于其相对简单和保守的生物合成逻辑,RiPP易于被工程化以获得表现出不同生理活性且难以合成的各种类似物。这篇综述旨在系统地介绍过去十年中发现的新型RiPP的各种生物活性和/或机制,尽管也简要介绍了选择性结构和生物合成机制的特征。几乎一半的病例涉及抗革兰氏阳性菌。同时,还详细讨论了越来越多的RiPP与抗革兰氏阴性菌、抗肿瘤、抗病毒等有关。最后但并非最不重要的是,我们总结了RiPP生物活动的一些学科,以指导未来的基因组挖掘以及药物发现和优化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent Advances in Discovery, Bioengineering, and Bioactivity-Evaluation of Ribosomally Synthesized and Post-translationally Modified Peptides

Recent Advances in Discovery, Bioengineering, and Bioactivity-Evaluation of Ribosomally Synthesized and Post-translationally Modified Peptides

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are of increasing interest in natural products as well as drug discovery. This empowers not only the unique chemical structures and topologies in natural products but also the excellent bioactivities such as antibacteria, antifungi, antiviruses, and so on. Advances in genomics, bioinformatics, and chemical analytics have promoted the exponential increase of RiPPs as well as the evaluation of biological activities thereof. Furthermore, benefiting from their relatively simple and conserved biosynthetic logic, RiPPs are prone to be engineered to obtain diverse analogues that exhibit distinct physiological activities and are difficult to synthesize. This Review aims to systematically address the variety of biological activities and/or the mode of mechanisms of novel RiPPs discovered in the past decade, albeit the characteristics of selective structures and biosynthetic mechanisms are briefly covered as well. Almost one-half of the cases are involved in anti-Gram-positive bacteria. Meanwhile, an increasing number of RiPPs related to anti-Gram-negative bacteria, antitumor, antivirus, etc., are also discussed in detail. Last but not least, we sum up some disciplines of the RiPPs’ biological activities to guide genome mining as well as drug discovery and optimization in the future.

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来源期刊
ACS Bio & Med Chem Au
ACS Bio & Med Chem Au 药物、生物、化学-
CiteScore
4.10
自引率
0.00%
发文量
0
期刊介绍: ACS Bio & Med Chem Au is a broad scope open access journal which publishes short letters comprehensive articles reviews and perspectives in all aspects of biological and medicinal chemistry. Studies providing fundamental insights or describing novel syntheses as well as clinical or other applications-based work are welcomed.This broad scope includes experimental and theoretical studies on the chemical physical mechanistic and/or structural basis of biological or cell function in all domains of life. It encompasses the fields of chemical biology synthetic biology disease biology cell biology agriculture and food natural products research nucleic acid biology neuroscience structural biology and biophysics.The journal publishes studies that pertain to a broad range of medicinal chemistry including compound design and optimization biological evaluation molecular mechanistic understanding of drug delivery and drug delivery systems imaging agents and pharmacology and translational science of both small and large bioactive molecules. Novel computational cheminformatics and structural studies for the identification (or structure-activity relationship analysis) of bioactive molecules ligands and their targets are also welcome. The journal will consider computational studies applying established computational methods but only in combination with novel and original experimental data (e.g. in cases where new compounds have been designed and tested).Also included in the scope of the journal are articles relating to infectious diseases research on pathogens host-pathogen interactions therapeutics diagnostics vaccines drug-delivery systems and other biomedical technology development pertaining to infectious diseases.
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