射血分数降低型心力衰竭成人右心导管血液动力学与糖化血红蛋白水平之间的关系。

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular Endocrinology & Metabolism Pub Date : 2023-06-21 eCollection Date: 2023-09-01 DOI:10.1097/XCE.0000000000000285
Gaspar Del Rio-Pertuz, Cristina Morataya, Kanak Parmar, Zeyad Elharabi, Daniel Davis, Mostafa Abohelwa, Ozman Ochoa, Alison Tran, Kenneth Nugent, David Paniagua, Erwin Argueta-Sosa
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引用次数: 0

摘要

本研究假设糖化血红蛋白(HbA1c)水平升高与射血分数降低型心力衰竭(HFrEF)患者右心导管检查(RHC)血流动力学参数异常有关:回顾性队列研究:对射血分数降低型心力衰竭(HFrEF)且既往未确诊糖尿病的成年患者进行右心导管检查,并在右心导管检查前后 30 天测量 HbA1c 水平。该研究排除了在 HbA1c 测量前 90 天内接受过输血的患者和已知患有糖尿病的患者。使用调整了年龄、性别和体重指数的单变量和多变量回归分析来检验 RHC 血液动力学参数与 HbA1c 水平之间的关联:共纳入 136 名患者,平均年龄为 55±15 岁,平均 HbA1c 为 5.99±0.64% 。未经调整的单变量模型显示,HbA1c 与菲克法和热稀释法得出的心脏指数(CI)、右心房压(RAP)和平均肺动脉压(MPAP)显著相关。经过多变量分析,HbA1c 每增加一个单位,热稀释法和 Fick 法的预期 CI 分别下降 0.19 和 0.26 升/分钟/平方米(P = 0.03 和 P <0.01)。HbA1c 每增加一个单位,预期 RAP 增加 2.39 mmHg(P = 0.01):左心室射血分数较低的患者在指数 RHC 之前或之后 30 天内测量到的 HbA1c 水平较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between right heart catheterization hemodynamics and glycosylated hemoglobin levels in adults with heart failure with reduced ejection fraction.

Association between right heart catheterization hemodynamics and glycosylated hemoglobin levels in adults with heart failure with reduced ejection fraction.

Association between right heart catheterization hemodynamics and glycosylated hemoglobin levels in adults with heart failure with reduced ejection fraction.

Association between right heart catheterization hemodynamics and glycosylated hemoglobin levels in adults with heart failure with reduced ejection fraction.

This study hypothesized that elevated glycosylated hemoglobin (HbA1c) levels are associated with abnormal right heart catheterization (RHC) hemodynamic parameters in patients with heart failure with reduced ejection fraction (HFrEF) and no prior diagnosis of diabetes.

Methods: Retrospective cohort study of adult patients with HFrEF and no prior diagnosis of diabetes who underwent RHC and had HbA1c levels measured 30 days before or after the RHC. This study excluded patients who had received blood transfusions within 90 days prior to HbA1c measurement and patients with known diabetes. Univariate and multivariate regression analyses adjusted for age, sex, and BMI were used to test for an association between RHC hemodynamic parameters and HbA1c levels.

Results: A total of 136 patients were included with a mean age of 55 ± 15 years and mean HbA1c was 5.99 ± 0.64%. Unadjusted univariate models showed that HbA1c is significantly associated with cardiac index (CI) by the Fick method and thermodilution, right atrial pressure (RAP), and mean pulmonary arterial pressure (MPAP). After multivariate analysis, for every one unit increase in HbA1c, there was a 0.19 and 0.26 L/min/m2 decrease in expected CI by thermodilution and by the Fick method (P = 0.03 and P < 0.01), respectively. For every one unit increase in HbA1c, there was a 2.39 mmHg increase in expected RAP (P = 0.01).

Conclusion: Elevated HbA1c levels measured within 30 days before or after the index RHC in patients with a left ventricular ejection fraction <40% were associated with congestive hemodynamic parameters.

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来源期刊
Cardiovascular Endocrinology & Metabolism
Cardiovascular Endocrinology & Metabolism CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.60
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24
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