化疗和放疗引起的口腔黏膜炎的治疗进展:一项系统综述。

Schilin Wen, Leonardo Brito, Javiera Santander, Gonzalo Conteras
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引用次数: 0

摘要

口腔黏膜炎(OM)是癌症患者在接受化疗或放疗时常见的并发症。它表现为口腔黏膜的炎症,有时会引起严重的后果,如饮食限制,说话困难,并可能重复感染。目的:本综述的目的是更新近五年来发表的关于癌症患者放疗和/或化疗引起的口腔黏膜炎治疗的证据。材料和方法:检索Pubmed、Scielo和Scopus,检索词为粘膜炎、口炎、治疗、治疗、口腔癌、口腔鳞状细胞癌、头颈癌和头颈癌,检索时间为2017年至2023年1月,检索词为网状词和自由词。系统审查是按照PRISMA指南进行的。结果:共检索到论文287篇,其中按标题和摘要筛选出86篇,经全文分析后纳入18篇。最常评估的变量是OM的严重程度、疼痛强度和愈合时间。治疗方式多种多样,包括药物、漱口水、基于植物提取物的药物、冷冻疗法和低强度激光疗法。结论:Dentoxol漱口水、车前草提取物、百里香蜂蜜提取物、氧化锌膏、复合维生素B联合GeneTime和服用l -谷氨酰胺可有效减轻OM的严重程度。多塞平漱口水和苯海拉明-利多卡因-抗酸漱口水的疼痛强度较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review.

Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review.

Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review.

Oral mucositis (OM) is a frequent complication in cancer patients who are undergoing chemotherapy or radiotherapy. It manifests as an inflammation of the oral mucosa, sometimes provoking severe consequences such as eating limitations, difficulty in speaking, and possibly superinfection.

Aim: The aim of this review was to update the evidence published during the last five years on the treatment of oral mucositis induced by radiotherapy and/or chemotherapy in patients with cancer.

Materials and method: A search was conducted in Pubmed, Scielo and Scopus, using the search terms mucositis, stomatitis, therapy, treatment, oral cancer, oral squamous cell carcinoma, head and neck cancer and head and neck carcinoma, with Mesh terms and free terms, from 2017 to January 2023. The systematic review was conducted in accordance with the PRISMA guidelines.

Results: A total 287 articles were retrieved, of which 86 were selected by title and abstract, and 18 were included after full-text analysis. The most frequently assessed variables were OM severity, pain intensity and healing time. Treatment types were diverse, and included drugs, mouthwashes, medicines based on plant extracts, cryotherapy and low-intensity laser therapies.

Conclusion: Dentoxol mouthwashes, Plantago major extract, thyme honey extract, zinc oxide paste, vitamin B complex combined with GeneTime, and the consumption of L-glutamine are effective in diminishing the severity of OM. Pain intensity was lower with doxepin mouthwashes and diphenhydramine-lidocaine-antacid mouthwashes.

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