嘌呤酶:哺乳动物代谢物的案例研究。

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Anthony M Pedley, Vidhi Pareek, Stephen J Benkovic
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引用次数: 15

摘要

在过去的15年里,我们已经揭示了一种新的机制,通过这种机制,细胞在从头合成嘌呤的过程中获得了更高的效率。这种机制依赖于新的嘌呤生物合成酶的区隔化,形成一种称为嘌呤酶体的动态复合物。在这篇综述中,我们强调了我们目前对嘌呤酶体的理解,重点是它的生物物理性质和功能以及调节其组装的细胞机制。我们提出了一种功能性嘌呤小体模型,其中它们由至少10种酶组成,这些酶位于线粒体附近,并通过代谢通道进行从头嘌呤生物合成。最后,我们讨论了与研究嘌呤酶体和类似代谢相关的挑战和机遇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Purinosome: A Case Study for a Mammalian Metabolon.

The Purinosome: A Case Study for a Mammalian Metabolon.

The Purinosome: A Case Study for a Mammalian Metabolon.

The Purinosome: A Case Study for a Mammalian Metabolon.

Over the past fifteen years, we have unveiled a new mechanism by which cells achieve greater efficiency in de novo purine biosynthesis. This mechanism relies on the compartmentalization of de novo purine biosynthetic enzymes into a dynamic complex called the purinosome. In this review, we highlight our current understanding of the purinosome with emphasis on its biophysical properties and function and on the cellular mechanisms that regulate its assembly. We propose a model for functional purinosomes in which they consist of at least ten enzymes that localize near mitochondria and carry out de novo purine biosynthesis by metabolic channeling. We conclude by discussing challenges and opportunities associated with studying the purinosome and analogous metabolons.

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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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