海马体容积指数显示了神经生物学对污染负担对青少年端粒长度影响的敏感性。

IF 3.4 3区 心理学 Q1 PSYCHOLOGY, DEVELOPMENTAL
Jonas G Miller, Jessica L Buthmann, Ian H Gotlib
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引用次数: 0

摘要

接触环境污染物与儿童和青少年的细胞衰老有关。然而,个体对环境污染物影响的敏感性或脆弱性可能会有所不同。海马体积越大,对社会环境的敏感性就越高。在探索性分析(N = 214)中,我们扩展了这一领域的工作,提供证据表明,青少年早期海马体积较大,反映了对邻里污染负荷对端粒长度影响的敏感性增加(标准化β = -0.40,95% CI[-0.65,-0.15])。相反,较小的海马体积似乎可以缓冲这种关联(标准化 β = 0.02)。在海马体积较大的青少年中,污染负担通过缩短基线端粒长度与大约2年后端粒长度的缩短间接相关(间接标准化β = -0.25,95% CI[-0.40,0.10])。对于这些青少年来说,生活在高污染或低污染的社区可能会使他们在青春期后期分别出现端粒较短或端粒较长的情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hippocampal volume indexes neurobiological sensitivity to the effect of pollution burden on telomere length in adolescents.

Exposure to environmental pollutants has been associated with cellular aging in children and adolescents. Individuals may vary, however, in their sensitivity or vulnerability to the effects of environmental pollutants. Larger hippocampal volume has emerged as a potential index of increased sensitivity to social contexts. In exploratory analyses (N = 214), we extend work in this area by providing evidence that larger hippocampal volume in early adolescence reflects increased sensitivity to the effect of neighborhood pollution burden on telomere length (standardized β = -0.40, 95% CI[-0.65, -0.15]). In contrast, smaller hippocampal volume appears to buffer this association (standardized β = 0.02). In youth with larger hippocampal volume, pollution burden was indirectly associated with shorter telomere length approximately 2 years later through shorter telomere length at baseline (indirect standardized β = -0.25, 95% CI[-0.40, 0.10]). For these youth, living in high or low pollution-burdened neighborhoods may predispose them to develop shorter or longer telomeres, respectively, later in adolescence.

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来源期刊
CiteScore
7.70
自引率
3.60%
发文量
34
期刊介绍: The mission of New Directions for Child and Adolescent Development is to provide scientific and scholarly presentations on cutting edge issues and concepts in the field of child and adolescent development. Each issue focuses on a specific new direction or research topic, and is peer reviewed by experts on that topic. Any topic in the domain of child and adolescent development can be the focus of an issue. Topics can include social, cognitive, educational, emotional, biological, neuroscience, health, demographic, economical, and socio-cultural issues that bear on children and youth, as well as issues in research methodology and other domains. Topics that bridge across areas are encouraged, as well as those that are international in focus or deal with under-represented groups. The readership for the journal is primarily students, researchers, scholars, and social servants from fields such as psychology, sociology, education, social work, anthropology, neuroscience, and health. We welcome scholars with diverse methodological and epistemological orientations.
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