习惯性运动对高脂肪饮食引起的肥胖的抗炎和生物调节作用涉及白色脂肪组织中的冠状结构和MCP-1。

IF 3.5 4区 医学 Q2 IMMUNOLOGY
Exercise Immunology Review Pub Date : 2023-01-01
Isabel Gálvez, María Dolores Hinchado, Leticia Martín-Cordero, Francisco Javier Morán-Plata, Gerry Graham, Javier Francisco-Morcillo, Eduardo Ortega
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引用次数: 0

摘要

巨噬细胞在脂肪组织中的积累及其炎症表型的改变是肥胖诱导炎症的一个标志,特别是形成被称为“冠状结构(CLS)”的炎症结构。运动可能是改善炎症相关并发症的关键策略,但重要的是要考虑到,尽管运动通常具有全身和局部抗炎作用,但这取决于基础炎症状态和运动方式。在这种情况下,“运动的生物调节作用”意味着减少或预防过度的炎症反应,也意味着保存或刺激先天反应。在目前的工作中,我们的目的是评估定期运动对高脂肪饮食诱导的肥胖小鼠脂肪组织炎症的影响,通过巨噬细胞浸润和表型以及CLS形成来反映,以及趋化因子MCP-1在这一过程中的潜在作用。结果显示,肥胖与MCP-1表达升高相关(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The anti-inflammatory and bioregulatory effects of habitual exercise in high-fat diet-induced obesity involve crown-like structures and MCP-1 in white adipose tissue.

Macrophage accumulation in the adipose tissue and changes in their inflammatory phenotype is a hallmark of obesity-induced inflammation, notably forming inflammatory structures known as "crown-like structures (CLS)". Exercise can be a key strategy to improve inflammation-related complications, but it is crucial to consider that, although exercise generally exerts systemic and local anti-inflammatory effects, this depends on the basal inflammatory status and exercise modality. In this context, the "bioregulatory effect of exercise" implies to achieve the reduction or prevention of an excessive inflammatory response and also the preservation or stimulation of the innate response. In the present work, our aim was to evaluate the effect of regular exercise on adipose tissue inflammation in high-fat diet-induced obesity in mice, as reflected by macrophage infiltration and phenotype, and CLS formation, together with a potential role for the chemokine MCP-1 in this process. Results showed that obesity is associated with greater MCP-1 expression (p<0.05), macrophage accumulation (p<0.05), and CLS presence (p<0.001). Regular exercise reduced macrophage accumulation (p<0.05), MCP-1 expression (p<0.01), and CLS presence (p<0.05) in obese mice; while it increased macrophage and CLS presence (p<0.01), MCP-1 expression (p<0.05), and M2 polarization (p<0.05) in lean mice. MCP-1 was associated with the proliferation of CLS, showing the first image demonstrating a potential role of this chemokine in the development of these structures. Altogether, these results confirm, for the first time, the "bioregulatory effect of exercise" in the adipose tissue: reducing inflammation in individuals with an elevated inflammatory setpoint, but stimulating this response of the immune system in healthy individuals.

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来源期刊
Exercise Immunology Review
Exercise Immunology Review 医学-免疫学
CiteScore
16.00
自引率
0.00%
发文量
7
期刊介绍: Exercise Immunology Review (EIR) serves as the official publication of the International Society of Exercise and Immunology and the German Society of Sports Medicine and Prevention. It is dedicated to advancing knowledge in all areas of immunology relevant to acute exercise and regular physical activity. EIR publishes review articles and papers containing new, original data along with extensive review-like discussions. Recognizing the diverse disciplines contributing to the understanding of immune function, the journal adopts an interdisciplinary approach, facilitating the dissemination of research findings from fields such as exercise sciences, medicine, immunology, physiology, behavioral science, endocrinology, pharmacology, and psychology.
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